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FLASH GENE
Symbol IGHV3-7 contributors: - updated : 04-11-2005
HGNC name immunoglobulin heavy variable 3-7
HGNC id 5620
Location 14q32.33      Physical location : -
Synonym symbol(s) HGNC5620, IGHV37
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text component of the cluster of the variable IGH genes which is located at the distal end of IGH@ (see symbol IGHV@)
MAPPING cloned Y linked N status provisional
Physical map
IGHD4-4 14q32.32-q32.33 immunoglobulin heavy diversity 4-4 IGHD3-3 14q32.32-q32.33 immunoglobulin heavy diversity 3-3 IGHD2-2 14q32.32-q32.33 immunoglobulin heavy diversity 2-2 IGHD1-1 14q32.32-q32.33 immunoglobulin heavy diversity 1-1 KIAA0125 14q32.33 immunoglobulin heavy diversity 1-1 IGHV6-1 14q32.32-q32.33 immunoglobulin heavy variable 6-1 IGHVII-1-1 14q32.32-q32.33 immunoglobulin heavy variable (II)-1-1 LOC9269 LOC192133 14q32.33 ribosomal protein S8 pseudogene IGHV1-2 14q32.32-q32.33 immunoglobulin heavy variable 1-2 IGHVIII-2-1 14q32.32-q32.33 immunoglobulin heavy variable (III)-2-1 IGHV1-3 14q32.32-q32.33 immunoglobulin heavy variable 1-3 IGHV4-4 14q32.32-q32.33 immunoglobulin heavy variable 4-4 IGHV2-5 14q32.32-q32.33 immunoglobulin heavy variable 2-5 IGHVIII-5-1 14q32.32-q32.33 immunoglobulin heavy variable (III)-5-1 IGHVIII-5-2 14q32.32-q32.33 immunoglobulin heavy variable (III)-5-2 IGHV3-6 14q32.32-q32.33 immunoglobulin heavy variable 3-6
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood/Hematopoieticbone marrow   
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a sequence of some 110 aminoacids folded to form a compact immunoglobulin domain with both ends joined together by a disulfide bond
  • three hypervariable regions (complementary-determining regions) located on the N terminal part
  • the remaining part being relatively constant and forming the framework
  • HOMOLOGY
    Homologene
    FAMILY Immunoglobulin superfamily
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • forming the antigen binding site together with the cognate region of the light chain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text humoral immunity, antibody synthesis
    PATHWAY
    metabolism
    signaling
    a component
  • component of the immunoglobulin molecules which are tetramers of two identical heavy chains and two identicallight chains, either kappa or lambda, bound by disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C-terminal end covalently bound to the DJ segment by the V(D)J recombination system (see RAG1, RAG2)
  • during the process, a random loss or gain of nucleotides occurs (junctional diversification)
  • bound by a disulfide bond to a variable light chain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS