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FLASH GENE
Symbol IGHG3 contributors: - updated : 17-06-2006
HGNC name immunoglobulin heavy constant gamma 3 (G3m marker)
HGNC id 5527
Location 14q32.33      Physical location : -
Synonym symbol(s) HGNC5527, DKZp686H1123, FLJ39988, FLJ40036, FLJ40253, FLJ40587, FLJ40789, FLJ40834, MGC45809, IGG3
DNA
TYPE functioning gene
MAPPING cloned Y linked N status confirmed
Physical map
ELK2P1 14q32.3 ELK2, member of ETS oncogene family, pseudogene 1 MGC27165 14q32.33 hypothetical protein MGC27165 IGHG3 14q32.33 immunoglobulin heavy constant gamma 3 (G3m marker) IGHD 14q32.33 immunoglobulin heavy constant delta IGHM 14q32.33 immunoglobulin heavy constant mu
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION
basic FUNCTION antigen binding
immune response
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
  • forming an homodimer of two D heavy chains bound by an unique disulfide bond
  • each heavy chain is bound to a light chain (kappa or lambda)
  • the N terminus of the heavy chain is bound to a V segment
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in ulcerative colitis
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS