Selected-GenAtlas references SOURCE GeneCards NCBI Gene Orphanet Ensembl IMGT
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IGHG1 contributors: mct - updated : 24-10-2017
HGNC name immunoglobulin heavy constant gamma 1 (G1m marker)
HGNC id 5525
Location 14q32.33      Physical location : -
Synonym symbol(s) IGG1
DNA
TYPE functioning gene
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Visualeyeanterior segmentcornea  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immuneimmunocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION unknown
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
  • forming an homodimer of two D heavy chains bound by an unique disulfide bond
  • each heavy chain is bound to a light chain (kappa or lambda)
  • the N terminus of the heavy chain is bound to a V segment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PHB/PHB2 and the CD86 cytoplasmic domain cooperate to mediate CD86 signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IGHG1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    IGHG1/CCND1 in t(11;14)in B-cell chronic lymphocytic leukemia;IGHG1/LHX4 in t(1;14); IGHG1/FOXP1 in t(3;14)in a sub-class of MALT lymphomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS