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FLASH GENE
Symbol IGFBP1 contributors: mct - updated : 25-06-2014
HGNC name insulin-like growth factor binding protein 1
HGNC id 5469
Location 7p12.3      Physical location : 45.927.958 - 45.933.266
Synonym name
  • IGF-binding protein 1
  • alpha-pregnancy-associated endometrial globulin
  • amniotic fluid binding protein
  • growth hormone independent-binding protein
  • placental protein 12
  • binding protein-28
  • binding protein-26
  • binding protein-25
  • Synonym symbol(s) IBP1, AFBP, PP12, IGF-BP25, hIGFBP-1
    DNA
    TYPE functioning gene
    STRUCTURE 5.31 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D7S484 - D7S2497 - [D7S2541 - D7S91 - D7S2427 - D7S519 - D7S2506 - D7S674 ] - D7S2422 - cen
    Authors Joyce (99)
    Text [IGFBP1 ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 1660 27 259 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunespleen   moderately
    Reproductivefemale systemuterus  highly
     female systemplacenta  specific
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text amniotic fluid, decidua, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 12 N terminal invariant cysteine residues
  • 6 C terminal invariant cysteine residues
  • a N terminal IGFBP motif
  • a central domain lacking cysteine residue, with a RGD motif
  • a thyroglobulin type-I domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Igfbp1
    ortholog to murine Igfbp1
    Homologene
    FAMILY
    CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • a portion of intracellular IGFBP1 protein localizes to mitochondria where it binds to the proapoptotic protein BAK1 and hinders BAK1 activation and apoptosis induction
  • basic FUNCTION
  • prolonging the half-life of the IGFs
  • inhibiting or stimulating the growth promoting effects of the IGFs on cell culture
  • altering the interaction of IGFs with their cell surface receptors
  • negative regulator of the BAK1-dependent pathway of apoptosis, whose expression integrates the transcriptional and mitochondrial functions of the TP53 tumor suppressor protein
  • major secreted protein of human decidual cells during gestation and, as a modulator of insulin-like growth factors or by independent mechanisms, regulates embryonic implantation and growth
  • its phosphorylation state influences the propensity of IGFBP1 to proteolysis
  • regulates human schwannoma proliferation, adhesion and survival
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text regulation of cell growth
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AHR paradoxically regulates IGFBP1 and LPL expressions in the liver
  • RHOC, and RAC1 are essential, for IGFBP1-induced extravillous trophoblast (EVT migration
  • TEAD4-stimulated IGFBP1 expression may be central to the mechanism by which TEAD4 attenuates blood glucose levels (
  • FOXO1 is an upstream regulator of IGFBP1
  • FOXO1/IGFBP1 axis is essential for PGR-dependent growth inhibition of endometrial epithelial cells
  • liver MTOR controls IGF1 bioavailability by regulation of protein kinase CSNK2A1 and IGFBP1 phosphorylation in fetal growth restriction
  • cell & other
    REGULATION
    activated by during liver regeneration
    Other regulated by insulin and corticoids
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   amplification    
    duplicated in an atypical Silver Russel syndrome
    tumoral     --over  
    in hepatocellular carcinomas
    constitutional     --over  
    associated with the severity of renal pathology in patients with IgA nephropathy
    tumoral     --over  
    in schwannoma at the mRNA level (PMID;
    constitutional     --over  
    during pregnancy compared to postpartum (two peaks, at week 17-24 and just before delivery, were observed)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential novel biomarker of abdominal aortic aneurysm (AAA), and he biological role of IGFBP1 in AAA pathogenesis could be related to the modulation on the effect of IGF1 on platelet aggregation (PMID;
  • low serum concentrations of IGFBP1 forms could be a marker of coronary risk
  • Therapy target
    ANIMAL & CELL MODELS