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FLASH GENE
Symbol IGF2BP3 contributors: mct - updated : 116-02-201
HGNC name insulin-like growth factor 2 mRNA binding protein 3
HGNC id 28868
Location 7p15.3      Physical location : 23.349.828 - 23.509.995
Synonym name
  • KH domain containing protein overexpressed in cancer
  • IGF2 mRNA binding protein 3
  • cancer/testis antigen 98
  • Synonym symbol(s) IMP3, VICKZ3, KOC1, IMP-3, CT98, DKFZp686F1078
    DNA
    TYPE functioning gene
    STRUCTURE 160.17 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4168 - 579 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell Homo sapiens
    Lymphoid/Immunelymphocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text ubiquitously during fetal development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two functional RNA recognition motifs (RRM)
  • four KH domains
  • HOMOLOGY
    interspecies homolog to murine Crdbp
    ortholog to murine Igf2bp3
    intraspecies homolog to IMP1
    Homologene
    FAMILY
  • IMP protein family
  • RNA binding proteins family
  • RRM IMP/VICKZ family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in transcriptional or postranscriptional regulation
  • may be involved in the regulation of RNA synthesis and metabolism
  • may have a role in normal growth and development
  • may have a role in physiologic regulation of IGF2 production
  • involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor
  • implicated in RNA regulatory processes such as intracellular RNA localization, RNA stability, and translational control
  • may play a role in cancer cell migration
  • play an important role in colorectal catrcinoma metastasis by shuttling requisite RNAs to the lamellipodia of migrating cells
  • play a role in RNA trafficking and stabilization and cell growth and migration during embryogenesis but which are down-regulated in adult tissue
  • oncofetal protein, which may play an important role in malignant transformation in esophageal adenocarcinoma
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA associating specifically with the 5'UTR of insulin-like growth factor II leader-3 mRNA
    small molecule
    protein
  • nuclear IGF2BP3-HNRNPM complex is important for the efficient synthesis of CCND1, CCND3 and CCNG1 and for the proliferation of human cancer cells
  • facilitates tumor immune escape by downregulating the stress-induced ligands ULBP2 and MICB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in pancreatic cancer cell lines and in pancreatic cancer tissue compared to normal pancreas and chronic pancreatitis tissue, as well as in tissues of other human tumors
    tumoral     --other  
    aberrant expression in diffuse large B-cell
    tumoral     --over  
    strongly and diffusely expressed in a large proportion of moderately/poorly differentiated lung adenocarcinomas
    tumoral     --over  
    in several epithelial malignancies, with increased expression correlating with aggressive behavior
    Susceptibility
    Variant & Polymorphism
    Candidate gene for Russel Silver syndrome
    Marker
  • can serve as a new biomarker to predict outcome for patients with clear cell carcinoma and other subtypes of ovarian carcinoma
  • highly sensitive and specific biomarker for the diagnosis of invasive esophageal adenocarcinoma and high-grade dysplasia
  • Therapy target
    ANIMAL & CELL MODELS