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FLASH GENE
Symbol IGF2BP2 contributors: mct - updated : 16-02-2011
HGNC name insulin-like growth factor 2 mRNA binding protein 2
HGNC id 28867
Location 3q27.2      Physical location : 185.361.527 - 185.542.827
Synonym name
  • IGF-II mRNA-binding protein 2
  • hepatocellular carcinoma autoantigen p62
  • VICKZ family member 2
  • IGF-II mRNA-binding protein 2
  • Synonym symbol(s) p62, IMP2, VICKZ2, IMP-2
    DNA
    TYPE functioning gene
    STRUCTURE 181.30 kb
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3676 66 599 - 1999 10190901
    - splicing 3547 61 556 - 1999 10190901
    lacking an alternate in-frame exon compared to variant 1
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     mouthtongue  highly
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemuteruscervix moderately
    Respiratoryrespiratory tractlarynx  predominantly
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell Homo sapiens
    Lymphoid/Immunelymphocyte Homo sapiens
    Muscularmyoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four KH domains
  • two RRM domains
  • HOMOLOGY
    Homologene
    FAMILY
  • IGF-II mRNA-binding protein (IMP) family
  • RRM IMP/VICKZ family
  • CATEGORY enzyme , regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • translational attenuation
  • regulating IGF2 translation
  • implicated in RNA regulatory processes such as intracellular RNA localization, RNA stability, and translational control
  • may play a role in cancer cell migration
  • play an important role in colorectal catrcinoma metastasis by shuttling requisite RNAs to the lamellipodia of migrating cells
  • regulates the expression of LIMS2 and TRIM54 proteins via direct binding to their mRNAs
  • involved in the posttranscriptional regulation of gene expression contributing to the control of adhesion structures and stable microtubules and have an important function in cellular motility
  • CELLULAR PROCESS protein, translation regulation
    PHYSIOLOGICAL PROCESS development
    text morphogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrant expression in diffuse large B-cell
    Susceptibility to type 2 diabetes (T2DM), and gestational diabetes
    Variant & Polymorphism SNP IGF2BP2 rs1470579 and rs4402960 polymorphisms may be associated with the development of T2DM
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS