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FLASH GENE
Symbol IGBP1 contributors: mct - updated : 10-10-2017
HGNC name immunoglobulin (CD79A) binding protein 1
HGNC id 5461
Corresponding disease
MRXS28 mental retardation, syndromic 28
Location Xq13.1      Physical location : 69.353.317 - 69.386.171
Genatlas name B cell signal transduction molecule alpha 4
Synonym name
  • alpha 4
  • immunoglobulin-binding protein 1
  • protein phosphatase 2A, regulatory subunit alpha-4
  • Synonym symbol(s) IBP1, ALPHA-4
    DNA
    TYPE functioning gene
    STRUCTURE 32.88 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ33610 Xq13.1 hypothetical protein FLJ33610 HCP43 Xq13.1 cytochrome c, somatic pseudogene TED Xq13.1 TED protein ED1 Xq12-q13.1 ectodermal dysplasia 1, anhidrotic LOC158835 Xq13.1 similar to bA351K23.5 (novel protein) LOC139562 Xq13.1 similar to bA351K23.4 (novel protein) IGBP1 Xq13.1-q13.4 immunoglobulin (CD79A) binding protein 1 FLJ25989 Xq13.1 FLJ25989 protein LOC158833 Xq13.1 hypothetical protein LOC158833 P2RY4 Xq13 pyrimidinergic receptor P2Y, G-protein coupled, 4 ARR3 Xq13.1 arrestin 3, retinal (X-arrestin) LOC347517 Xq13.1 similar to DNA segment, Chr 9, Brigham & Womens Genetics 0185 expressed LOC51248 Xq13.1 hypothetical protein LOC51248 KIF4A Xq13.1 kinesin family member 4A OBDPF Xq13.1 osteoblast differentiation promoting factor DLG3 Xq13.1 discs, large (Drosophila) homolog 3 (neuroendocrine-dlg) TEX11 Xq12-q13.1 testis expressed sequence 11 SLC7A3 Xq12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 LOC392488 X similar to Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) SNX12 Xq12-q13.1 sorting nexin 12
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1679 - 339 - 2001 11371618
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SH3 domain and seven possible phosphorylation sites
  • C-terminal region playing a key role in the binding interaction of PP2P2CA and MID1
  • HOMOLOGY
    interspecies homolog to yeast TAP42 protein
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in regulation of the catalytic activity of type 2a-related serine/threonine phosphatases
  • might play a critical role in regulating T cell motility mediated by CTLA4
  • plays a required role in regulating the assembly and maintenance of adaptive PPP2CA phosphatase complexes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated to surface IgM-receptor associating with PPP2CA, PPP2CB
  • interacting with MID2
  • in addition to PPP2CA, IGBP1 interacts with UBR5 and PABPC1, suggesting its involvement in multiple steps in the MTOR pathway that leads to translation initiation and cell-cycle progression
  • reduction of PPP2CA activity due to an enhanced IGBP1-PPP2CA interaction contributes directly to chemical carcinogen-induced tumorigenesis
  • LTF binds IGBP1 and promotes the acceleration of cellular apoptosis
  • IGBP1 interacts with MID1, a microtubule-associated ubiquitin E3 ligase that appears to regulate the function of PPP2CA
  • IGBP1 phosphoprotein binds to the protein phosphatase 2A catalytic subunit (PPP2CA) to regulate PP2A activity, and to poly(A)-binding protein (PABP) and progestin-inducible UBR5
  • MID1 catalyze the polyubiquitination of, IGBP1, a protein regulator of protein phosphatase 2A (PPP2CA)
  • a significant fraction of total PPP6C is associated with IGBP1, whereas a minimal fraction of total PPP2CA is associated with IGBP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRXS28
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS