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FLASH GENE

Symbol

IGBP1

contributors: mct - updated : 10-10-2017

HGNC name	immunoglobulin (CD79A) binding protein 1
HGNC id	5461

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MRXS28 mental retardation, syndromic 28
Location	Xq13.1      Physical location : 69.353.317 - 69.386.171
Genatlas name	B cell signal transduction molecule alpha 4
Synonym name	alpha 4
	immunoglobulin-binding protein 1
	protein phosphatase 2A, regulatory subunit alpha-4
Synonym symbol(s)	IBP1, ALPHA-4

DNA

TYPE	functioning gene
STRUCTURE	32.88 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001551 7 - 1679 NP_001542 - 339 - 2001 11371618

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Endocrine pancreas         Nervous brain         Reproductive female system uterus cervix   highly   female system breast mammary gland   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum cardiac     Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a SH3 domain and seven possible phosphorylation sites
	C-terminal region playing a key role in the binding interaction of PP2P2CA and MID1

HOMOLOGY

interspecies

homolog to yeast TAP42 protein

Homologene

FAMILY

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	may be involved in regulation of the catalytic activity of type 2a-related serine/threonine phosphatases
	might play a critical role in regulating T cell motility mediated by CTLA4
	plays a required role in regulating the assembly and maintenance of adaptive PPP2CA phosphatase complexes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6

INTERACTION

DNA

RNA

small molecule

protein	associated to surface IgM-receptor associating with PPP2CA, PPP2CB
	interacting with MID2
	in addition to PPP2CA, IGBP1 interacts with UBR5 and PABPC1, suggesting its involvement in multiple steps in the MTOR pathway that leads to translation initiation and cell-cycle progression
	reduction of PPP2CA activity due to an enhanced IGBP1-PPP2CA interaction contributes directly to chemical carcinogen-induced tumorigenesis
	LTF binds IGBP1 and promotes the acceleration of cellular apoptosis
	IGBP1 interacts with MID1, a microtubule-associated ubiquitin E3 ligase that appears to regulate the function of PPP2CA
	role for MID1 in the regulation of IGBP1 that is likely to impact the stability and activity level of PPP2CA
	IGBP1 phosphoprotein binds to the protein phosphatase 2A catalytic subunit (PPP2CA) to regulate PP2A activity, and to poly(A)-binding protein (PABP) and progestin-inducible UBR5
	MID1 catalyze the polyubiquitination of, IGBP1, a protein regulator of protein phosphatase 2A (PPP2CA)
	a significant fraction of total PPP6C is associated with IGBP1, whereas a minimal fraction of total PPP2CA is associated with IGBP1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRXS28

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS