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FLASH GENE

Symbol

IFT43

contributors: mct - updated : 22-12-2020

HGNC name	intraflagellar transport 43 homolog (Chlamydomonas)
HGNC id	29669

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CETD3 cranioectodermal dysplasia 3 RP81 retinitis pigmentosa 81 SRTD18 short-rib thoracic dysplasia 18 with polydactyly
Location	14q24.3      Physical location : -
Synonym name	hypothetical protein LOC112752
	chromosome 14 open reading frame 179
Synonym symbol(s)	FLJ32173, MGC16028, C14orf179, CETD3, CED3, RP81, SRTD18

DNA

TYPE	functioning gene
STRUCTURE	98.31 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001102564 10 - 850 23 208 - 2017 28973684 NM_052873 9 - 865 - 213 - 2017 28973684 NM_001255995 4 - 869 NP_001242924 - 113 - 2017 28973684

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx         Nervous nerve       highly Reproductive female system uterus       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	involved in retrograde IFT (intraflagellar transport)
	both IFT43 and IFT140 are involved in mobilizing ciliary precursors from the cytoplasmic pool during flagellar regeneration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

IFT-A protein complex consists of IFT43, WDR35, IFT122, TTC21B, IFT140 and WDR19 and is associated with THM1 and TULP3

INTERACTION

DNA

RNA

small molecule

protein	RASA1 is required for appropriate cytoplasmic localization of the retrograde IFT-A protein IFT43
	IFT43 directly interacts with WDR35 and loss of IFT43 results in instability of IFT-A

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CETD3 , SRTD18 , RP81

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS