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FLASH GENE
Symbol IFT22 contributors: mct - updated : 21-10-2011
HGNC name intraflagellar transport 22
HGNC id 21895
Location 7q22.1      Physical location : -
Synonym name
  • RAB, member RAS oncogene family-like 5
  • Synonym symbol(s) FLJ13225, FLJ14117, RABL5, FAP9
    DNA
    TYPE functioning gene
    STRUCTURE 8.45 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2351 - 108 - -
    5 - 2428 - 185 - -
    4 - 2338 - 155 - -
    5 - 2459 - 108 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Nervousbrain    
    Reproductivefemale systembreastmammary gland  
     female systemovary   
     male systemtestis   
     male systemprostate   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies homolog to murine Rabl5
    intraspecies homolog to IFT122
    Homologene
    FAMILY RAS superfamily of GTP-binding protein
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • move in an IFT-like manner in the flagella, but its function in ciliogenesis is controversial
  • binding of IFT22 to the intraflagellar transport complex is likely essential for flagellum assembly
  • IFT22 is an active GTPase with low intrinsic GTPase activity
  • nucleotide-dependent recruitment of the BBSome to the basal body by IFT22 regulates BBSome entry into cilia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS