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FLASH GENE
Symbol IFNL2 contributors: mct - updated : 30-05-2013
HGNC name interferon, lambda 2
HGNC id 18364
Location 19q13.13      Physical location : -
Synonym name
  • interleukin 28A (interferon, lambda 2)
  • Synonym symbol(s) IL-28A, IL28A
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text component of a cluster of three related cytokine genes (IL28A, IL28B, IL29)
    STRUCTURE 1.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    intraspecies paralog to IL28B and IL29
    Homologene
    FAMILY a cytokine related to type I interferons and IL-10 families
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • play a critical role in response to microbial challenge and activate the JAK/STAT signaling pathway
  • IFNL1, IFNL2, IFNL3, IL28RA are induced by viruses and mediate antiviral activity, but type III IFNs have an important, specific functional niche at the immune/epithelial interface, as well as in the regulation of Th2 cytokines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with a heterodimeric class II cytokine receptor (IL10RB-IL28RA)
    cell & other
    REGULATION
    induced by viral infection
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS