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FLASH GENE
Symbol IFNL1 contributors: mct - updated : 29-05-2013
HGNC name interferon, lambda 1
HGNC id 18363
Location 19q13.13      Physical location : -
Synonym name
  • interleukin 29 (interferon, lambda 1)
  • Synonym symbol(s) IL-29, IL29
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text component of a cluster of three related cytokine genes (IL28A, IL28B, IL29)
    STRUCTURE 2.35 kb     5 Exon(s)
    regulatory sequence Promoter
    Binding site   HRE
    text structure
  • positive-regulatory domain I and IFN-stimulated response element sites are predominantly involved in the DNA-mediated IFNL1 activation
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 856 - 200 - 2003 12469119
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon   Homo sapiens
    Lymphoid/Immunetonsils     Homo sapiens
    Respiratorylung     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
  • type-I interferons and IL-10 family
  • Class II cytokine family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a critical role in response to microbial challenge and activating the JAK/STAT signaling system
  • cytokine produced in response to viral infection, activates both monocytes and macrophages producing a restricted panel of cytokines and may therefore be important in activating innate immune responses at the site of viral infection
  • may regulate myeloma cell biology and could prove to be therapeutically important
  • mast cell-derived IFNL1 has the potential to be involved in the pathogenesis of allergic inflammation
  • IFNL1, and IFNA2 differ in their ability to modulate IL12 production by TLR-activated macrophages and exhibit differential regulation of the IFNGR1 expression
  • class II cytokine, displaying numerous immune functions other than its anti-viral and antiproliferation activities
  • IFNL1 -induced TLR3 expression is involved in antiviral activity of IFNL1 in keratinocytes
  • IFNL1, IFNL2, IFNL3, IL28RA are induced by viruses and mediate antiviral activity, but type III IFNs have an important, specific functional niche at the immune/epithelial interface, as well as in the regulation of Th2 cytokines
  • inducing activation of JAK/STAT signaling in hepatocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with a heterodimeric class II cytokine receptor (IL10B-IL28RA)
  • critical role for the activated RPS6SKA1 in IFNL1 signaling
  • XRCC6 is a novel DNA sensor inducing the IFNL1 activation
  • cell & other
    REGULATION
    induced by viral infection
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    potential of IFNL1, alone or in combination with IFNG, in the treatment of human lung carcinoma
    ANIMAL & CELL MODELS