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FLASH GENE
Symbol IFNB1 contributors: mct - updated : 23-11-2012
HGNC name interferon, beta 1, fibroblast
HGNC id 5434
Location 9p21.3      Physical location : 21.077.104 - 21.077.943
Synonym name
  • fibroblast interferon
  • Synonym symbol(s) IFB, IFF, IFNB, MGC96956
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 0.84 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked Y status confirmed
    Map pter - D9S54 - D9S33 - IFNB1 - D9S126 - D9S3 - D9S104 - D9S43 - D9S19 - cen
    Authors Fountain (92),NIH/CEPH (92)
    Physical map
    IFNB1 9p22 interferon, beta 1, fibroblast IFNW1 9p22 interferon, omega 1 IFNA21 9p22 interferon, alpha 21 LOC392289 9 similar to Interferon omega-1 precursor (Interferon alpha-II-1) IFNA4 9p22 interferon, alpha 4 LOC392290 9 similar to Interferon omega-1 precursor (Interferon alpha-II-1) IFNA7 9p22 interferon, alpha 7 IFNA10 9p22 interferon, alpha 10 G13P1 9p22 interferon alpha-L pseudogene LOC392291 9 similar to Interferon omega-1 precursor (Interferon alpha-II-1) IFNA16 9p22 interferon, alpha 16 IFNA17 9p22 interferon, alpha 17 LOC392292 9 similar to Interferon omega-1 precursor (Interferon alpha-II-1) IFNA14 9p22 interferon, alpha 14
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 840 22.3 187 - 2007 17675303
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • alpha/beta interferon family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having antiviral, antibacterial and anticancer activities
  • secreted cytokine that complexes with type I IFN receptors to initiate a coordinated cellular program leading to widespread viral resistance
  • augments eosinophil adhesion-inducing activity of endothelial cells
  • modulates protein synthesis in the central nervous system
  • constitutive IFNB1 expression regulates HSP70AA1 levels to help maintain dendritic cells in a competent state for efficient priming of effector T cells
  • has the ability to induce apoptosis of melanoma cells
  • acts to suppress the generation of autoimmune-inducing Th17 cells during the development of disease as well as modulating pro-inflammatory mediators
  • immunomodulator, but may also act directly on neural stem/progenitor cells (NPCs) in the central nervous system
  • contributes to RAS transformation, supporting the notion that oncogene-induced cytokines play important roles in oncogene transformation
  • has broad immunomodulatory effects on many types of immune cells
  • may potentially induce antigen-specific T cells to produce IL10, which in turn negatively regulate Th17-mediate inflammatory and autoimmune response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CASP2 activation is commonly associated with induction of IFNB1-induced apoptosis in IFNB1-sensitive melanoma cells
  • stimulates IL10 production by activating the JAK1- and PI3K-signaling pathways
  • FOXO3 is a new IKBKE-controlled check-point of regulation of IFNB1 expression
  • is a novel negative regulator of IFNB1 production
  • cell & other
    REGULATION
    induced by in dendritic cells responding to viral infection (response is very broad, ranging from few tens to several thousands of mRNA copies)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in dermatomyositis and polymyositis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunemultiple sclerosis
    major disease-modifying agent used for the treatment of multiple sclerosis (MS)
    ANIMAL & CELL MODELS