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FLASH GENE
Symbol IFNA2 contributors: mct - updated : 30-05-2015
HGNC name interferon, alpha 2
HGNC id 5423
Location 9p22      Physical location : 21.384.254 - 21.385.396
Synonym symbol(s) INFA2, IFNA
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 1.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map see IFN1@
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to C.elegans y54g2a.t
Homologene
FAMILY interferon alpha,beta and delta family
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • IFNL1, and IFNA2 differ in their ability to modulate IL12 production by TLR-activated macrophages and exhibit differential regulation of the IFNGR1 expression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RS4 is a novel USP18-binding protein that can be used to boost the host innate immunity to control HCV, and potentially other viruses that are sensitive to IFNA2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS