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FLASH GENE
Symbol IFNA1 contributors: mct/npt - updated : 21-02-2017
HGNC name interferon, alpha 1
HGNC id 5417
Location 9p22      Physical location : 21.440.439 - 21.441.315
Synonym name
  • interferon alpha-D
  • IFN-alpha 1b
  • Synonym symbol(s) IFNA@, IFL, IFN, IFNA13, IFN-ALPHA, MGC138207, MGC138505, MGC138507
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 0.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    IFNA16 9p22 interferon, alpha 16 IFNA17 9p22 interferon, alpha 17 LOC392292 9 similar to Interferon omega-1 precursor (Interferon alpha-II-1) IFNA14 9p22 interferon, alpha 14 IFNAP22 9p21 interferon, alpha pseudogene 22 IFNA5 9p22 interferon, alpha 5 KIAA1354 9p22 KIAA1354 protein IFNA6 9p22 interferon, alpha 6 IFNA13 9p22 interferon, alpha 13 IFNA2 9p22 interferon, alpha 2 IFNA8 9p22 interferon, alpha 8 LOC392293 9 similar to Interferon omega-1 precursor (Interferon alpha-II-1) IFNA1 9p22 interferon, alpha 1 LOC392294 9 similar to interferon-alpha IFNT1 9p21.3 interferon tau-1 LOC347217 9p21.3 similar to KH-type splicing regulatory protein (FUSE binding protein 2); KH-type splicing regulatory protein (FUSE-binding protein 2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 876 21 189 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 23 amino acids signal peptide (2,6 kDa)
  • isoforms Precursor an 166 amino acids mature peptide (19.1 kDa)
    HOMOLOGY
    interspecies homolog to C.elegans c47e12.9
    homolog to chimpanzee IFNA13 (98.41 pc)
    Homologene
    FAMILY
  • interferon alpha, beta and delta family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • playing a critical role in antiviral and antitumor protection and immune regulation
  • involved in the pathogenesis of certain neurological disorders
  • key factor in autoimmune disease
  • may control uveitis by promoting induction of IL10-producing T-cells
  • multifunctional cytokine important in the innate immune system, that may playing a major pathogenic role in the development of systemic lupus erythematosus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STAT1(essential signaling molecule in many IFNA -regulated processes)
  • represents a fourth class of extracellular ligands for CR2 and interacts with the same domain as the other three ligands
  • IFNA1-induced the expression of IFIT3 and STAT1 in THP-1 cells, and this process was significantly antagonized by the specific inhibitors of both PRKCD and MAPK8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility systemic lupus
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS