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FLASH GENE
Symbol IFITM1 contributors: mct - updated : 17-03-2012
HGNC name interferon induced transmembrane protein 1 (9-27)
HGNC id 5412
Location 11p15.5      Physical location : 313.990 - 315.271
Synonym name
  • interferon-induced protein 17
  • interferon-inducible protein 9-27
  • leu-13 antigen
  • Synonym symbol(s) 9-27, IFI17, LEU13, CD225
    DNA
    TYPE functioning gene
    STRUCTURE 1.28 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    Binding site   HRE
    text structure interferon-stimulable response element (ISRE)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 733 - 125 - 2007 16847454
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    two transmembrane domains
    mono polymer complex
    HOMOLOGY
    interspecies homolog to C.elegans H06H21.7
    Homologene
    FAMILY
  • IFN-induced transmembrane protein family
  • IFITM family
  • CATEGORY regulatory , antigen , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in cell-growth control and immune response
  • component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals
  • implicated in cell-to-cell homotypic adhesion and antiproliferative signaling in leukocytes and endothelial cells
  • could inhibit the activity of extracellular signal-regulated kinase, enhance the transcriptional activity of TP53 and stabilize the TP53 protein by inhibiting TP53 phosphorylation on Thr55
  • essential mediator of interferon-g-induced antiproliferation
  • IFITM1, IFITM2, IFITM3 mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
  • activated CTNNB signaling pathway including IFITM1 might play an important role in a subset of Peutz-Jeghers syndrome polyps
  • act as antiviral restriction factor
  • IFITM1, IFITM2, IFITM3 are important components of the innate immune system to restrict HIV-1 infection
  • IFIT1 and IFITM1 serve as important molecules to restrict HCV infection, and they may have implications in the development of therapeutic modalities
  • IFITM1, IFITM2, IFITM3 are potentially involved in the differentiation and cell proliferation during heart development
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • does not have receptor activity, it does form a complex with CD81–CD19–CD21 and amplifies signal transduction in B lymphocytes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • localized in caveolae of the plasma membrane and could interact with CAV1 (interaction between IFITM1 and CAV1 could enhance the inhibitory effect of CAV1 on ERK activation)
  • cell & other
    REGULATION
    induced by interferon alpha/beta(IFNA/IFNB), interferon gamma(IFNG),X-ray,angiotensin 2 (A-II)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in chronic myeloid leukemia with good prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS