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Symbol IFITM1 contributors: mct - updated : 17-03-2012
HGNC name interferon induced transmembrane protein 1 (9-27)
HGNC id 5412
Location 11p15.5      Physical location : 313.990 - 315.271
Synonym name
  • interferon-induced protein 17
  • interferon-inducible protein 9-27
  • leu-13 antigen
  • Synonym symbol(s) 9-27, IFI17, LEU13, CD225
    TYPE functioning gene
    STRUCTURE 1.28 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    Binding site   HRE
    text structure interferon-stimulable response element (ISRE)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390028 11 similar to Olfactory receptor 4F3 LOC387731 11 similar to bA476I15.3 (novel protein similar to septin) LOC387732 11 LOC387732 RYD5 11p15.5 ligand binding protein RYD5 ODF3 11p15.5 outer dense fiber of sperm tails 3 BET1L 11p15.5 blocked early in transport 1 homolog (S. cerevisiae) like RIC-8 11p15.5 likely ortholog of mouse synembryn SIRT3 11p15.5 sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) PSMD13 11p15.5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 NALP6 11p15 NACHT, leucine rich repeat and PYD containing 6 FLJ22635 11p15.5 hypothetical protein FLJ22635 LOC387733 11 similar to putative haemopoietic membrane protein MRPS24P1 11p15.4 mitochondrial ribosomal protein S24 pseudogene IFITM2 11p15.5 interferon induced transmembrane protein 2 (1-8D) IFITM1 11p15.5 interferon induced transmembrane protein 1 (9-27) IFITM3 11p15.5 interferon induced transmembrane protein 3 (1-8U) PKP3 11p15 plakophilin 3 LOC387734 11 similar to beta 1,4-N-acetylgalactosaminyltransferase-transferase-III FLJ25045 11p15.5 hypothetical protein FLJ25045 SIGIRR 11p15.5 single Ig IL-1R-related molecule PTDSS2 11p15 phosphatidylserine synthase 2 RNH 11p15.5 ribonuclease/angiogenin inhibitor LOC387735 11 similar to Collagen alpha 1(V) chain precursor HRAS 11p15.5 v-Ha-ras Harvey rat sarcoma viral oncogene homolog DKFZp761L1518 11p15.5 hypothetical protein DKFZp761L1518 MGC35138 11p15.5 hypothetical protein MGC35138 C11orf13 11p15,5 chromosome 11 open reading frame 13 KIAA1542 11p15.5 CTD-binding SR-like protein rA9 IRF7 11p15,5 interferon regulatory factor 7 MUCDHL 11p15,5 mucin and cadherin-like SCT 11p15.5 secretin DRD4 11p15.5 dopamine receptor D4 LOC387736 11 LOC387736 DEAF1 11p15,5 deformed epidermal autoregulatory factor 1 (Drosophila) LOC283232 11p15.5 hypothetical protein LOC283232 EPS8L2 11p15.5 EPS8-like 2 TALDO1 11p15.5-p15.4 transaldolase 1 FLJ34283 11p15.5 hypothetical protein FLJ34283 NS3BP 11p15.5 NS3BP BM88 11p15.5 NS3BP SLC25A22 11p15.5 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 LOC387737 11 LOC387737 LRDD 11pter-p15.5 leucine-rich and death domain containing
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 733 - 125 - 2007 16847454
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemovary  highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    at STAGE
    two transmembrane domains
    mono polymer complex
    interspecies homolog to C.elegans H06H21.7
  • IFN-induced transmembrane protein family
  • IFITM family
  • CATEGORY regulatory , antigen , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in cell-growth control and immune response
  • component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals
  • implicated in cell-to-cell homotypic adhesion and antiproliferative signaling in leukocytes and endothelial cells
  • could inhibit the activity of extracellular signal-regulated kinase, enhance the transcriptional activity of TP53 and stabilize the TP53 protein by inhibiting TP53 phosphorylation on Thr55
  • essential mediator of interferon-g-induced antiproliferation
  • IFITM1, IFITM2, IFITM3 mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
  • activated CTNNB signaling pathway including IFITM1 might play an important role in a subset of Peutz-Jeghers syndrome polyps
  • act as antiviral restriction factor
  • IFITM1, IFITM2, IFITM3 are important components of the innate immune system to restrict HIV-1 infection
  • IFIT1 and IFITM1 serve as important molecules to restrict HCV infection, and they may have implications in the development of therapeutic modalities
  • IFITM1, IFITM2, IFITM3 are potentially involved in the differentiation and cell proliferation during heart development
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    PHYSIOLOGICAL PROCESS immunity/defense
    signaling signal transduction
    a component
  • does not have receptor activity, it does form a complex with CD81–CD19–CD21 and amplifies signal transduction in B lymphocytes
    small molecule
  • localized in caveolae of the plasma membrane and could interact with CAV1 (interaction between IFITM1 and CAV1 could enhance the inhibitory effect of CAV1 on ERK activation)
  • cell & other
    induced by interferon alpha/beta(IFNA/IFNB), interferon gamma(IFNG),X-ray,angiotensin 2 (A-II)
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in chronic myeloid leukemia with good prognosis
    Variant & Polymorphism
    Candidate gene
    Therapy target