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FLASH GENE
Symbol IFIT5 contributors: mct - updated : 23-06-2015
HGNC name interferon-induced protein with tetratricopeptide repeats 5
HGNC id 13328
Location 10q23.31      Physical location : 91.174.324 - 91.180.758
Synonym name
  • retinoic acid- and interferon-inducible protein (58kD)
  • interferon-induced 58 kDa protein
  • Synonym symbol(s) RI58, p58, ISG58
    DNA
    TYPE functioning gene
    STRUCTURE 6.43 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC35136 10q23.31 hypothetical protein MGC35136 PTEN 10q23.3 phosphatase and tensin homolog (mutated in multiple advanced cancers 1) FLJ11218 10q23.31 hypothetical protein FLJ11218 LOC142910 10q23.31 similar to Triacylglycerol lipase, gastric precursor (Gastric lipase) (GL) LOC389992 10 similar to ribosomal protein L7 LIPF 10q23.33 lipase, gastric LOC118934 10q23.31 similar to hypothetical protein 9930115F20 LOC389993 10 similar to lipase A precursor; Lipase A, lysosomal acid, cholesterol esterase LOC340654 10q23.31 similar to bA304I5.1 (novel lipase) MGC22805 10q23.31-q23.32 hypothetical protein MGC22805 AMSH-LP 10q23.33 associated molecule with the SH3 domain of STAM (AMSH) like protein DKFZp761K1824 10q23.32 hypothetical protein DKFZp761K1824 ACTA2 10q22.3-q23.1 actin, alpha 2, smooth muscle, aorta TNFRSF6 10q24.1 tumor necrosis factor receptor superfamily, member 6 CH25H 10q23 cholesterol 25-hydroxylase LIPA 10q23.2-q23.3 lipase A, lysosomal acid, cholesterol esterase (Wolman disease) IFIT2 10q23.3 interferon-induced protein with tetratricopeptide repeats 2 IFIT4 10q23.3 interferon-induced protein with tetratricopeptide repeats 4 LOC389994 10 similar to Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) LOC387699 10 similar to Interferon-induced protein with tetratricopeptide repeats 1 IFIT1 10q25-q26 interferon-induced protein with tetratricopeptide repeats 1 IFIT5 10q23.3 interferon-induced protein with tetratricopeptide repeats 5 LOC387700 10 similar to expressed sequence AW210596 PANK1 10q22.3-q23 pantothenate kinase 1 FLJ37201 10q23.32 hypothetical protein FLJ37201 MPHOSPH1 10q23.33 M-phase phosphoprotein 1 LOC119358 10q23.32 similar to Small nuclear ribonucleoprotein Sm D2 (snRNP core protein D2) (Sm-D2) HTR7 10q22-q24 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) RPP30 10q23.32-q23.33 ribonuclease P (30kD) ANKRD1 10q23.33 ankyrin repeat domain 1 (cardiac muscle)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 4034 54 482 - 2011 2331750
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Endocrinepancreas    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight TPR repeats
  • helical domain that houses a positively charged cavity designed to specifically engage only single-stranded PPP-RNA, thus distinguishing it from the canonical cytosolic sensor of double-stranded viral PPP-RNA, DDX58
  • RNA-binding site in IFIT5 is a deep and narrow pocket
  • HOMOLOGY
    Homologene
    FAMILY IFI family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton
    text
  • co-localizes partly with mitochondria
  • basic FUNCTION
  • recognizes cellular RNA instead of protein partners
  • compartmentalized cellular RNA binding activity as a mechanism for IFIT5 function
  • can directly recognize viral RNA bearing a 5 prime-triphosphate group (PPP-RNA), which is a molecular signature that distinguishes it from host RNA
  • is an important enhancer in innate immune response
  • has comparable affinity for RNAs with diverse phosphate-containing 5prime-ends, excluding the higher eukaryotic mRNA cap
  • innate immune response protein IFIT5 having RNA recognition specificity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA IFIT5 binds precursor and processed tRNAs, as well as other RNA polymerase III transcripts
    small molecule
    protein
  • interacts with DDX58 and MAVS
  • cell & other
    REGULATION
    induced by retinoic acid and interferon
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS