Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IFIT5 contributors: mct - updated : 23-06-2015
HGNC name interferon-induced protein with tetratricopeptide repeats 5
HGNC id 13328
Location 10q23.31      Physical location : 91.174.324 - 91.180.758
Synonym name
  • retinoic acid- and interferon-inducible protein (58kD)
  • interferon-induced 58 kDa protein
  • Synonym symbol(s) RI58, p58, ISG58
    DNA
    TYPE functioning gene
    STRUCTURE 6.43 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 4034 54 482 - 2011 2331750
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Endocrinepancreas    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight TPR repeats
  • helical domain that houses a positively charged cavity designed to specifically engage only single-stranded PPP-RNA, thus distinguishing it from the canonical cytosolic sensor of double-stranded viral PPP-RNA, DDX58
  • RNA-binding site in IFIT5 is a deep and narrow pocket
  • HOMOLOGY
    Homologene
    FAMILY IFI family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton
    text
  • co-localizes partly with mitochondria
  • basic FUNCTION
  • recognizes cellular RNA instead of protein partners
  • compartmentalized cellular RNA binding activity as a mechanism for IFIT5 function
  • can directly recognize viral RNA bearing a 5 prime-triphosphate group (PPP-RNA), which is a molecular signature that distinguishes it from host RNA
  • is an important enhancer in innate immune response
  • has comparable affinity for RNAs with diverse phosphate-containing 5prime-ends, excluding the higher eukaryotic mRNA cap
  • innate immune response protein IFIT5 having RNA recognition specificity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA IFIT5 binds precursor and processed tRNAs, as well as other RNA polymerase III transcripts
    small molecule
    protein
  • interacts with DDX58 and MAVS
  • cell & other
    REGULATION
    induced by retinoic acid and interferon
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS