basic FUNCTION
| recognizes cellular RNA instead of protein partners |
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compartmentalized cellular RNA binding activity as a mechanism for IFIT5 function |
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can directly recognize viral RNA bearing a 5 prime-triphosphate group (PPP-RNA), which is a molecular signature that distinguishes it from host RNA |
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is an important enhancer in innate immune response |
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has comparable affinity for RNAs with diverse phosphate-containing 5prime-ends, excluding the higher eukaryotic mRNA cap |
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innate immune response protein IFIT5 having RNA recognition specificity |