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FLASH GENE
Symbol IFIT2 contributors: - updated : 14-06-2006
HGNC name interferon-induced protein with tetratricopeptide repeats 2
HGNC id 5409
Location 10q23.3      Physical location : 91.061.705 - 91.069.032
Synonym name interferon, alpha-inducible protein (MW 54kD)
Synonym symbol(s) G10P2, IFNAI3, ISG54K, IFI54
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
FLJ14600 10q23.31 hypothetical protein FLJ14600 MGC35136 10q23.31 hypothetical protein MGC35136 PTEN 10q23.3 phosphatase and tensin homolog (mutated in multiple advanced cancers 1) FLJ11218 10q23.31 hypothetical protein FLJ11218 LOC142910 10q23.31 similar to Triacylglycerol lipase, gastric precursor (Gastric lipase) (GL) LOC389992 10 similar to ribosomal protein L7 LIPF 10q23.33 lipase, gastric LOC118934 10q23.31 similar to hypothetical protein 9930115F20 LOC389993 10 similar to lipase A precursor; Lipase A, lysosomal acid, cholesterol esterase LOC340654 10q23.31 similar to bA304I5.1 (novel lipase) MGC22805 10q23.31-q23.32 hypothetical protein MGC22805 AMSH-LP 10q23.33 associated molecule with the SH3 domain of STAM (AMSH) like protein DKFZp761K1824 10q23.32 hypothetical protein DKFZp761K1824 ACTA2 10q22.3-q23.1 actin, alpha 2, smooth muscle, aorta TNFRSF6 10q24.1 tumor necrosis factor receptor superfamily, member 6 CH25H 10q23 cholesterol 25-hydroxylase LIPA 10q23.2-q23.3 lipase A, lysosomal acid, cholesterol esterase (Wolman disease) IFIT2 10q23.3 interferon-induced protein with tetratricopeptide repeats 2 IFIT4 10q23.3 interferon-induced protein with tetratricopeptide repeats 4 LOC389994 10 similar to Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) LOC387699 10 similar to Interferon-induced protein with tetratricopeptide repeats 1 IFIT1 10q25-q26 interferon-induced protein with tetratricopeptide repeats 1 IFIT5 10q23.3 interferon-induced protein with tetratricopeptide repeats 5 LOC387700 10 similar to expressed sequence AW210596 PANK1 10q22.3-q23 pantothenate kinase 1 FLJ37201 10q23.32 hypothetical protein FLJ37201 MPHOSPH1 10q23.33 M-phase phosphoprotein 1 LOC119358 10q23.32 similar to Small nuclear ribonucleoprotein Sm D2 (snRNP core protein D2) (Sm-D2) HTR7 10q22-q24 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Hearing/Equilibriumear   highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Amphiphilic
STRUCTURE
motifs/domains
  • six tetratricopeptide repeats (TPR)with two interacting amphipathic alpha helices named domains A and D
  • secondary structure two alpha helices
    HOMOLOGY
    Homologene
    FAMILY IFIT family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by interferon alpha-inducible
    interferon beta,interleukin 1,retinoic acid,viral infections…
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS