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FLASH GENE
Symbol IFIT2 contributors: mct - updated : 21-02-2017
HGNC name interferon-induced protein with tetratricopeptide repeats 2
HGNC id 5409
Location 10q23.31      Physical location : 91.061.705 - 91.069.032
Synonym name interferon, alpha-inducible protein (MW 54kD)
Synonym symbol(s) G10P2, IFNAI3, ISG54K, IFI54, GARG-39, IFI-54, IFI-54K, IFIT-2, ISG-54K, ISG54, P54, cig42
DNA
TYPE functioning gene
STRUCTURE 7.33 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
FLJ14600 10q23.31 hypothetical protein FLJ14600 MGC35136 10q23.31 hypothetical protein MGC35136 PTEN 10q23.3 phosphatase and tensin homolog (mutated in multiple advanced cancers 1) FLJ11218 10q23.31 hypothetical protein FLJ11218 LOC142910 10q23.31 similar to Triacylglycerol lipase, gastric precursor (Gastric lipase) (GL) LOC389992 10 similar to ribosomal protein L7 LIPF 10q23.33 lipase, gastric LOC118934 10q23.31 similar to hypothetical protein 9930115F20 LOC389993 10 similar to lipase A precursor; Lipase A, lysosomal acid, cholesterol esterase LOC340654 10q23.31 similar to bA304I5.1 (novel lipase) MGC22805 10q23.31-q23.32 hypothetical protein MGC22805 AMSH-LP 10q23.33 associated molecule with the SH3 domain of STAM (AMSH) like protein DKFZp761K1824 10q23.32 hypothetical protein DKFZp761K1824 ACTA2 10q22.3-q23.1 actin, alpha 2, smooth muscle, aorta TNFRSF6 10q24.1 tumor necrosis factor receptor superfamily, member 6 CH25H 10q23 cholesterol 25-hydroxylase LIPA 10q23.2-q23.3 lipase A, lysosomal acid, cholesterol esterase (Wolman disease) IFIT2 10q23.3 interferon-induced protein with tetratricopeptide repeats 2 IFIT4 10q23.3 interferon-induced protein with tetratricopeptide repeats 4 LOC389994 10 similar to Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) LOC387699 10 similar to Interferon-induced protein with tetratricopeptide repeats 1 IFIT1 10q25-q26 interferon-induced protein with tetratricopeptide repeats 1 IFIT5 10q23.3 interferon-induced protein with tetratricopeptide repeats 5 LOC387700 10 similar to expressed sequence AW210596 PANK1 10q22.3-q23 pantothenate kinase 1 FLJ37201 10q23.32 hypothetical protein FLJ37201 MPHOSPH1 10q23.33 M-phase phosphoprotein 1 LOC119358 10q23.32 similar to Small nuclear ribonucleoprotein Sm D2 (snRNP core protein D2) (Sm-D2) HTR7 10q22-q24 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3505 - 472 - 2014 23867918
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Hearing/Equilibriumear   highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Amphiphilic
STRUCTURE
motifs/domains
  • 9 tetratricopeptide repeat-like motifs and associate to form domain-swapped dimers
  • C-terminal part folds into a super-helical structure and has an extensively positively-charged nucleotide-binding channel on its inner surface
  • secondary structure two alpha helices
    HOMOLOGY
    Homologene
    FAMILY IFIT family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • role of IFIT2 in the induction of apoptosis via a mitochondrial pathway
  • is one of the most highly responsive interferon-stimulated genes
  • may prevent oral squamous cell carcinoma (OSCC) metastasis
  • IFIT1 and IFIT2 contribute significantly to the regulation of HBV replication, likely at both transcriptional and posttranscriptional steps
  • IFN-stimulated IFIT2 via enhanced IRF3 phosphorylation upregulates the secretion of proinflammatory cytokines
  • is the interferon-induced protein that prevents vesicular stomatitis virus (VSV) infection of neurons of both the peripheral and the central nervous systems, thus inhibiting the consequent neuropathy, but it is dispensable for protecting the cells of other tissues from VSV infection
  • specific interferon-induced protein, IFIT2, is the protein that protects neurons from VSV infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFIT3 binding negatively regulates the apoptotic effects of IFIT2
  • positive feedback loop between phosphorylated STAT1 and IFIT1, IFIT2, IFIT3
  • AJUBA represses the expression of IFIT2 gene, an interferon-stimulated gene and a known apoptosis inducer and tumour suppressor to mediate its resistance to apoptosis
  • cell & other
    REGULATION
    induced by interferon alpha-inducible
    interferon beta,interleukin 1,retinoic acid,viral infections…
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • valuable prognostic marker in oral squamous cell carcinoma
  • Therapy target
    ANIMAL & CELL MODELS
  • in Ifit2(-/-) mice, vesicular stomatitis virus (VSV), injected subcutaneously into the footpad, entered the proximal lymph node, where it replicated and infected the nodal nerve endings