| basic FUNCTION
| RNA-dependent ATPase, playing a central role in an intracellular signal transduction pathway that can lead to the activation of the IFN-beta promoter |
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may contribute to apoptosis induction during terminal differentiation and during IFN treatment |
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may be having a role in protecting the host from viral infection by sensing viral nucleic acid in the cytoplasm and triggering a cellular antiviral and apoptotic response |
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cytoplasmic DEX(D/H) helicase protein that can induce signaling in response to RNA ligands, including those from viral infections (Murali 2008) |
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cytoplasmic helicase that mediates induction of interferon response to viral RNA (Nejentsev 2009) |
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cytosolic pattern recognition receptor detecting single-stranded or double-stranded RNA in virally infected cells (Li 2009) |
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recognize single-stranded RNA with 5prime triphosphates and double-stranded RNA (dsRNA) to initiate innate antiviral immune responses (Li 2009) |
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controls the local expression of cytokines and chemokines during a viral infection (Colli 2010) |
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may contribute to the pathogenesis of diabetes by modifying the beta-cell responses to a viral infection (Colli 2010) |
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may thus modulate beta-cell apoptosis and/or local release of inflammatory mediators in the course of a viral infection by acting, at least in part, at the pancreatic beta-cell level (Colli 2010) |
