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FLASH GENE

Symbol

IFI16

contributors: mct/ - updated : 05-07-2007

HGNC name	interferon, gamma-inducible protein 16
HGNC id	5395

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q22      Physical location : 158.979.681 - 159.024.943
Synonym name	interferon-inducible myeloid differentiation transcriptional activator
Synonym symbol(s)	INFGIP1, MGC9466, PYHIN2, ifi-16

DNA

TYPE	functioning gene
STRUCTURE	45.26 kb     11 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005531 11 - 2750 NP_005522 - 729 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Digestive esophagus       highly   pharynx       moderately Lymphoid/Immune lymph node       highly   thymus       highly Reproductive female system uterus     moderately Respiratory respiratory tract larynx     highly Skin/Tegument skin       moderately Urinary bladder       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective       highly Connective bone     moderately Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a DNA binding domain
	a PAAD/DAPIN/PYRIN domain
	two HIN-200 domains, consisting of two consecutive OB domains

HOMOLOGY

interspecies

homolog to chimpanzee IFI16 (97.94 pc)

Homologene

FAMILY

IFI-200/HIN-200 family of proteins

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	controling cellular proliferation by modulating the functions of cell cycle regulatory factors including P53 and the retinoblastoma protein
	may be involved in myeloid differentiation
	acting as transcriptional regulator and as interaction partners of proteins involved in immunomodulatory and apoptotic processes
	required for proinflammatory gene stimulation by IFN-gamma through the NF-kappaB complex

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

interacting with ICAM1 (mediates ICAM1 stimulation by TNF-alpha through the NF-kappaB pathway, thus reinforcing the role of the IFI16 molecule in the inflammation process)

cell & other

REGULATION

induced by

interferon alpha or gamma inducible in myeloid cells

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in ulcerative colitis and Crohn's disease

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS