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FLASH GENE
Symbol IER3 contributors: mct/npt - updated : 13-11-2009
HGNC name immediate early response 3
HGNC id 5392
Location 6p21.33      Physical location : 2.003.905 - 30.712.327
Synonym name
  • PACAP-responsive gene 1
  • gly96, mouse, homolog of
  • differentiation-dependent gene 2
  • immediate early gene X1
  • expressed in pancreatic carcinoma
  • radiation-inducible immediate-early gene IEX-1
  • Synonym symbol(s) DIF2, IEX1, PRG1, GLY96, IEX-1L, IEX-1
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 1.35 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure
  • 3'ARE elements
  • 5' flancking region containing binding sites for transcription factors including NF-kappa-B, CEBP and SP1 and for the P53 tumor suppressor
  • hexameric repeat DNA sequence in the promoter mediating vitamin D3 repression
  • MAPPING cloned Y linked   status provisional
    Map pter - D6S1558 - IER3 - D6S273 - D6S1666 - D6S1542 - D6S1645 - D6S291 - D6S1576 - D6S1548 - D6S1562 - D6S1575 - D6S1616 - cen
    Authors Gene Map (98)
    Physical map
    TRIM39 6p21.3 tripartite motif-containing 39 C6orf135 6p21.32 chromosome 6 open reading frame 135 MICC 6p21.3 MHC class I polypeptide-related sequence C LOC346173 6p21.32 similar to Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial precursor (Succinyl-CoA synthetase, betaA chain) (SCS-betaA) (ATP-specific succinyl-CoA synthetase beta subunit) RANP1 6p21.32 RAN, member RAS oncogene family pseudogene 1 HLA-E 6p21.3 major histocompatibility complex, class I, E GNL1 6p21.3 guanine nucleotide binding protein-like 1 PRR3 6p21.32 proline-rich polypeptide 3 ABCF1 6p21.33 ATP-binding cassette, sub-family F (GCN20), member 1 PPP1R10 6p21.3 protein phosphatase 1, regulatory subunit 10 MRPS18B 6p21.3 mitochondrial ribosomal protein S18B C6orf134 6p21.32 chromosome 6 open reading frame 134 C6orf136 6p21.32 chromosome 6 open reading frame 136 DHX16 6p21.3 DEAH (Asp-Glu-Ala-His) box polypeptide 16 KIAA1949 6p21.3 KIAA1949 protein NRM 6p21.31 nurim (nuclear envelope membrane protein) MDC1 6pter-p21.3 mediator of DNA damage checkpoint 1 OK/SW-cl.56 6p21.32 beta 5-tubulin FLOT1 6p21.3 flotillin 1 IER3 6p21.3 immediate early response 3 DDR1 6p21.3 discoidin domain receptor family, member 1 VARS2L 6p21.33 valyl-tRNA synthetase 2-like GTF2H4 6p21.3 general transcription factor IIH, polypeptide 4, 52kDa LOC389376 6 similar to GSGL541 DPCR1 6p21.32 similar to GSGL541 LOC389377 6 similar to KMQK697 C6orf15 6p21.3 chromosome 6 open reading frame 15 PSORS1C1 6p21.3 psoriasis susceptibility 1 candidate 1 CDSN 6p21.3 corneodesmosin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1254 16 156 - Garcia, Pietzsch (1998)
    short isoform IEX1S
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrinepancreas    
    Hearing/Equilibriumearinnercochlea highly
    Nervousnervecranial nerve  highly
    Reproductivefemale systemuteruscervix highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialbarrier/lining   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunelymphocyte
    Muscularmyocyte
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-linked glycosylation and phosphorylation sites (Shen 2006)
  • HOMOLOGY
    interspecies homolog to C.elegans f56c9.9
    Homologene
    FAMILY
  • IER3 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • type II membrane protein
  • specifically shuttled to and from the nucleus
  • basic FUNCTION
  • inhibiting apoptosis involved in NFKB mediate survival cell and due to FAS or tumor necrosis factor type alpha
  • biomechanically controlled nuclear factor -kappa B target inhibiting cardiomyocyte hypertrophy, counter balancing early hypertrophic responses in activated cardiomyocytes
  • modulates apoptosis, cellular growth, mechanical strain-induced cardiac hypertrophy, and vascular intimal hyperplasia (Kumar 2004)
  • may regulate apoptosis by directly interacting with various proteins involved in the control of apoptotic pathways (Kumar 2004)
  • stress response gene involved in growth control and modulation of apoptosis
  • playing a critical role in regulation of intracellular reactive oxygen species homeostasis (Shen 2006)
  • stress-inducible protein that is involved in the regulation of cell proliferation and apoptosis (Sasada 2008)
  • plays a complex role in the regulation of apoptosis
  • critical role in the NF-kappaB dependent regulation of apoptotic responses
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS development
    text embryomic development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPHB2(ERK) substrate having a dual role in EPHB2 signaling by acting both as an EPHB2 downstream effector mediating survival and as a regulator of EPHB2 activation
  • coordinated action of MCL1, IER3, and BCL2L11 controls cell death and survival (new regulatory circuit) (Yoon 2009)
  • interacts with several proteins of which at least four are known to play a role in the regulation of apoptosis (Kumar 2004)
  • cell & other
    REGULATION
    activated by during the early response of cardiomyocytes to hypertrophic stimuli
    induced by ionizing radiation and activators of PRKC
    okadaic acid and tnf-alpha
    12-O tetrade canoylphorbol-13-acetate
    Other monocytes/macrophages differentiation-dependent gene
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in tumor tissues may be associated with a better prognosis in pancreatic cancer (Sasada 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS