basic FUNCTION
| catalyzing the degradation of the essential amino acid L-tryptophan to N-formylkynurenine |
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heme-containing enzyme, which catalyzes the initial and rate-determining step of L-tryptophan (L-Trp) metabolism via the kynurenine pathway (Lu 2009) |
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plays an important role in immune escape through suppressing T-cell function (Li 2009) |
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catalyzing the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen |
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suppresses T-cell responses and promotes immune tolerance in mammalian pregnancy, tumour resistance, chronic infection, autoimmunity and allergic inflammation |
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acting as a bridge between dendritic cells and CD4+ regulatory T cells |
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metabolizing tryptophan to N-formyl-kynurenine under certain pathophysiological conditions (Hofmann 2010) |
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might be involved in chronic inflammatory diseases, such as atherosclerosis, morbid obesity and chronic heart disease (Hofmann 2010) |
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role for IDO1 in the regulation of blood pressure, although the contribution of IDO1 to sepsis-induced hypotension is smaller that that of NOS2 (Hofmann 2010) |
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contributes to arterial vessel relaxation and the control of blood pressure (Wang 2010) |
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having role in retinal pigment epithelial cell-mediated immune modulation (Park 2010) |