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FLASH GENE
Symbol IDH3G contributors: - updated : 02-05-2005
HGNC name isocitrate dehydrogenase 3 (NAD+) gamma
HGNC id 5386
Location Xq28      Physical location : 153.051.221 - 153.059.967
Synonym symbol(s) IDHG
EC.number 1.1.1.41
DNA
TYPE functioning gene
SPECIAL FEATURE head to head, opposite orientation
text head to head with SSR4
STRUCTURE 8.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
text structure CpG island shared with SSR4
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 1500 - 394 - Brenner
- splicing - - 406 fetus, liver, spleen Brenner
- splicing - - - - Brenner
33 C terminal AA replaced by 20 differal residues
- - - - - widely Brenner
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 pancreas exocrine    
Nervousbrain    
Reproductivefemale systembreastmammary gland  
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure heterooligomer of alpha, beta, gamma subunit
mono polymer heteromer
HOMOLOGY
interspecies homolog to murine Idh3g
Homologene
FAMILY isocitrate and isopropylmalate dehydrogenase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
basic FUNCTION
  • isocitrate dehydrogenase 3,gamma subunit,NADH dependent,catalyzing the third step of citric acid cycle
  • catalyzing the oxidative decarboxylation of isocitrate into alpha-ketoglutarate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS