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FLASH GENE
Symbol ICT1 contributors: mct - updated : 11-08-2004
HGNC name immature colon carcinoma transcript 1
HGNC id 5359
Location 17q25.1      Physical location : 73.008.779 - 73.017.355
Synonym name digestion substraction 1
Synonym symbol(s) DS-1, DS1
DNA
TYPE functioning gene
STRUCTURE 8.60 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 888 23.5 206 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cell lineage
cell lines highly expressed in undifferentiated colon carcinoma cells (HT29-D4); lowly, in differentiated colon carcinoma cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • a GGQ motif at the active site
  • HOMOLOGY
    interspecies ortholog to murine Ict1
    homolog to yeast YOL114C
    homolog to C.elegans R02F2.2
    Homologene
    FAMILY
  • prokaryotic/mitochondrial release factor family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • with C12orf65, have partially overlapping functions (Antonicka 2010)
  • has codon-independent peptidyl-tRNA hydrolase activity (Antonicka 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS