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FLASH GENE
Symbol ICOSLG contributors: - updated : 05-09-2006
HGNC name inducible T-cell co-stimulator ligand
HGNC id 17087
Location 21q22.3      Physical location : 45.646.723 - 45.660.834
Synonym name
  • cDNA sequence, expressed in brain, 60kDa, related to chicken CD80-like precursor
  • B7-like protein Gl50
  • B7 homolog 2
  • CD275 antigen
  • ICOS ligand precursor
    • Synonym symbol(s) KIAA0653, GL50, B7RP1, B7H2, ICOSL, CD275, LICOS
    DNA
    TYPE functioning gene
    STRUCTURE 14.00 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain    
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Respiratoryepithelial cell
    Urinarytubular cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one Ig-like C2-type (immunoglobulin-like) domain
  • one Ig-like V-type (immunoglobulin-like) domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to chicken CD80-like precursor
    Homologene
    FAMILY immunoglobulin superfamily, BTN/MOG family
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a costimulatory signal for T-cell proliferation and cytokine secretion
  • inducing also B-cell proliferation and differentiation into plasma cells
  • may play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function
  • may facilitate progression of acute myeloid leukemia
  • may participate in antigen presentation by epithelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text positive regulation of activated T cell proliferation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other up-regulated by TNF-alpha
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Icosl -/- mice are healthy and fertile but have a reduced IgG1 production and affinity maturation, indicating a defect in T cell responses. Also have impaired T and B-cell interaction and germinal center formation