basic FUNCTION
| major regulator of the adaptive immune system, required for effective T cell dependent immune responses |
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also critical for CD40-mediated antibody class switching |
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enhancing all basic T-cell responses to a foreign antigen, namely proliferation, secretion |
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of lymphokines, up-regulation of molecules mediating cell-cell interaction |
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critically involved in perpetuating inflammation in chronically immune-mediated disorders of the peripheral nervous system |
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critical involvement in T cell help for late B cell differentiation, class-switching and memory B cell generation |
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could enhance the cytotoxic activity of cytokine-induced killer cells, in part, by augmenting cytokine secretion and prolonging cell survival |
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important for the effector function of T cells, especially for Th2 and T cell dependent B cell responses |
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CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity |
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activational signal of Th17 cells during chronic intestinal inflammation, suggesting that under some conditions, control of ICOS expression may help to suppress chronic intestinal inflammation |
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vital role for ICOS signaling in the generation and maintenance of human T(H)17 cells |
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by altering effector T-cell populations differentially, ICOS signaling modulates tuberculosis control in the late stage of infection |
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ICOS-ICOSLG signal plays a direct role in proliferation and differentiation of thyroid follicular cells (TFC) and may exert important effects in the initiation, maintenance and exaggeration of autoimmune responses in local tissue |
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crucial in mediating T cell differentiation and function after allergen contact and thereby strongly affect the immunologic decision between tolerance or allergy development |
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crucial role of ICOS for the generation and suppressive function of Tregs conveying respiratory tolerance |
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ICOS/ICOSLG interaction is a central event in immunosuppression of tumor-associated memory CD4(+) T cells |
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ICOS costimulation-dependent translational control may ensure targeted delivery of IL4 to cognate B cells during T-B collaborations in the germinal center |
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TNFRSF4 and ICOS act in a cooperative, nonredundant manner to maximize and prolong the T follicular helper (Tfh) response that is generated after acute virus infection |