Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ICMT contributors: mct/npt/pgu - updated : 21-08-2009
HGNC name isoprenylcysteine carboxyl methyltransferase
HGNC id 5350
Location 1p36.31      Physical location : 6.281.254 - 6.296.044
Synonym name
  • prenylcysteine carboxyl methyl-transferase
  • protein-S isoprenylcysteine O-methyltransferase
  • Synonym symbol(s) PCMT, PPMT, HSTE14, PCCMT, MST098, MSTP098, MGC39955
    EC.number 2.1.1.100
    DNA
    TYPE functioning gene
    STRUCTURE 14.79 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC126772 1p36.31 similar to erythrocyte membrane-associated giant protein antigen 332 NPHP4 1p36.22 nephronophthisis 4 LOC388590 1 LOC388590 KCNAB2 1p36.3 potassium voltage-gated channel, shaker-related subfamily, beta member 2 CHD5 1p36.23 chromodomain helicase DNA binding protein 5 RPL22 1p36.3-p36.2 ribosomal protein L22 LOC388591 1 hypothetical gene supported by AK128246 FLJ32096 1p36.23 hypothetical protein FLJ32096 ICMT 1p36.21 isoprenylcysteine carboxyl methyltransferase MGC40168 1p36.23 hypothetical protein MGC40168 LOC390992 1 similar to helix-loop-helix transcription factor GPR153  G protein-coupled receptor 153 BACH 1p36.2 G protein-coupled receptor 153 LOC388592 1 similar to Transcription factor HES-2 (Hairy and enhancer of split 2) ESPN 1p36.31-p36.11 espin TNFRSF25 1p36.2 tumor necrosis factor receptor superfamily, member 25 KIAA0720 1p36.23 tumor necrosis factor receptor superfamily, member 25 FLJ23323 1p36.23 hypothetical protein FLJ23323 TAS1R1 1p36.23 taste receptor, type 1, member 1 HKR3 1p36.31 GLI-Kruppel family member HKR3 KIAA0469 1p36.23 KIAA0469 gene product PHF13 1p36.23 PHD finger protein 13 MGC33488 1p36.23 hypothetical protein MGC33488 FLJ10737 1p36.23 hypothetical protein FLJ10737 CAMTA1 1p36.31-p36.23 calmodulin binding transcription activator 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing initiation site 4815 31.9 284 ubiquitous, highly in cerebellum and putamen 2007 17347446
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six predicted membrane-spanning-domains
  • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Icmt
    homolog to Drosophila CG11268
    homolog to C.elegans M01E11.1
    homolog to rattus Icmt
    Homologene
    FAMILY
  • isoprenylcysteine o-methyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    basic FUNCTION
  • catalyzing the post-translational methylation of isoprenylated C-terminal cysteine residues
  • catalyzes methylation of proteins containing a C-terminal CAAX motif
  • modulates endothelial cell apoptosis
  • CELLULAR PROCESS protein, post translation, targeting
    cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • divalent cations (probably Zn2+)
  • protein interacting witrh RAC3 (importance of ICMT-catalyzed methylation on RAC3 function)
    cell & other
    REGULATION
    activated by TNFalpha, GTPgammaS
    inhibited by retinoic acid
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    induces endothelial cell apoptosis through HSP90B1
    constitutional       loss of function
    decreased Ras methylation and activity and the activation of the downstream signaling molecules Akt, ERK-1, and ERK-2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potential target for reducing the growth of KRAS- and BRAF -induced malignancies
    ANIMAL & CELL MODELS