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FLASH GENE
Symbol ICK contributors: mct/npt/pgu - updated : 15-05-2013
HGNC name intestinal cell (MAK-like) kinase
HGNC id 21219
Corresponding disease
ECO endocrine-cerebro-osteodysplasia
Location 6p12.1      Physical location : 52.866.097 - 52.926.600
Synonym name
  • Mak-related kinase
  • intestinal cell kinase
  • laryngeal cancer kinase 2
  • serine/threonine protein kinase
  • Synonym symbol(s) KIAA0936, LCK2, MGC46090, MRK
    EC.number 2.7.11.22
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 60.50 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter- D6S2393 - D6S1218E - ICK - D6S2402 - D6S1623 - GSTA@ - cen
    Physical map
    IL17 2q31 interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) IL17F 6p12 interleukin 17F SLC25A20P 6p12 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 pseudogene MCM3 6p12 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) C6orf33 6p12.1 chromosome 6 open reading frame 33 EFHC1 6p12.1 EF-hand domain (C-terminal) containing 1 TRAM2 6p21.3 translocation associated membrane protein 2 TMEM14A 6p12.3 transmembrane protein 14A LOC391927 6 similar to class-alpha glutathione S-transferase LOC391928 6 similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha) GSTA2 6p12.2 glutathione S-transferase A2 LOC391929 6 similar to glutathione transferase (EC 2.5.1.18) alpha-3 [similarity] - human GSTA1 6p12.2 glutathione S-transferase A1 GSTAP1 6p12.2 glutathione S-transferase A pseudogene 1 GSTA5 6p12.1 glutathione S-transferase A5 FLJ32293 6p12.3 hypothetical protein FLJ32293 GSTA3 6p12 glutathione S-transferase A3 GSTA4 6p12 glutathione S-transferase A4 RN7SK 6pter-p25 RNA, 7SK, nuclear ICK 6p12.3-p11.2 intestinal cell (MAK-like) kinase FBXO9 6p12.3-p11.2 F-box only protein 9 GCM1 6p21-p12 glial cells missing homolog 1 (Drosophila) LOC389398 6 LOC389398 ELOVL5 6p21.1-p12.1 ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) LOC391930 6 similar to ribosomal protein L31 LOC391931 6 similar to replication protein A3, 14kDa; replication protein A3 (14kD) GCLC 6p12 glutamate-cysteine ligase, catalytic subunit LOC391932 6 similar to bA345L23.2 (novel protein with BTB/POZ (broad complex Tramtrack bric-a-brac/Pox virus and zinc finger) domain) LRRC1 6p12.1 leucine-rich repeat-containing 1 C6orf142 6p12.2-p12.1 chromosome 6 open reading frame 142
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 6127 - 632 - 2000 10699974
    15 - 6238 - 632 - 2000 10699974
    - - 1806 - 292 - 2000 10699974
  • with an alternative C terminus
  • predominantly in the cytoplasm
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
    Nervousbrainbasal nucleicorpus callosum highly
     brainhindbraincerebellum moderately
     braindiencephalonhypothalamus moderately
     spinal cord   highly
    Reproductivefemale systemovary  moderately
     male systemtestis  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth   
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal catalytic domains, related to mitogen-activated protein kinases (MAPKs) and containing a corresponding TDY motif
  • a dual phosphorylation site found in mitogen-activating protein (MAP) kinases
  • C-terminal noncatalytic domains
  • HOMOLOGY
    interspecies homolog to rattus S/T-protein kinase
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • CDK subfamily
  • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • plays a key role in the development of multiple organ systems
  • nuclear Cdc2-related kinase, prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs
  • may play a role in cardiac development
  • playing an important role in intestinal epithelial cell proliferation and differentiation
  • highly conserved serine/threonine protein kinase, that supports cell proliferation and G(1) cell cycle progression
  • important role for ICK in modulating the activity of MTOR through phosphorylation of Raptor Thr-908, implicating a potential signaling mechanism by which ICK regulates cell proliferation and division
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Mg2+
  • protein
  • interacts with the MTOR/Raptor complex in cells, and is able to phosphorylate Raptor Thr-908
  • cell & other
    REGULATION
    activated by dual phophorylation of the TDY motif (Y-159 and T-157), such that it autophosphorylates at Y-159
    ASSOCIATED DISORDERS
    corresponding disease(s) ECO
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS