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FLASH GENE
Symbol ICAM3 contributors: mct - updated : 20-04-2013
HGNC name intercellular adhesion molecule 3
HGNC id 5346
Location 19p13.3-p13.2      Physical location : 10.444.451 - 10.450.345
Synonym symbol(s) CDW50, ICAMR, ICA3, CD50
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • promoter exhibits a leukocyte-specific activity, as its activity is significantly higher in ICAM-3+ hematopoietic cell lines, and is is negatively regulated by RUNX1, RUNX3
    • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
     bone marrow    Homo sapiensAdult
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticmature hematopoietic Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • a signal sequence,
  • an extracellular region with five Ig-like domains
  • a single transmembrane segment (1TM)
  • a cytoplasmic C terminus, containing a positively charged aminoacid cluster in the juxtamembrane cytoplasmic domain, ERM proteins binding
    • HOMOLOGY
    Homologene
    FAMILY Ig superfamily, ICAM subfamily
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION functioning not only as an adhesion molecule, but also as a potent signalling molecule
    CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for LFA1, counterreceptor
  • interacting with moesin and promoting its redistribution to the uropod of T-lymphocytes during cell polarization
  • interacting with CD209 (Geijtenbeek 2000)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS