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FLASH GENE
Symbol ICAM2 contributors: - updated : 19-05-2006
HGNC name intercellular adhesion molecule 2
HGNC id 5345
Location 17q23-q25      Physical location : 62.079.955 - 62.097.994
Synonym name cell differentiation antigen CD102
Synonym symbol(s) CD102
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map cen - TNFAIP1 - ERBB2 - TOP2A - BRCA1 BRCA1 - NFE2L1 - NME1 - HLF HLF - TRIM25 - BCL5 BCL5 ,MPO ,SFRS1 - TBX2 - PECAM1 - DDX5 ,PRKCA - ICAM2 - GH2 ,PRKAR1A - GRB2 - CDK3 - FOXJ1 - qter
Authors Bärlund (98)
Physical map
HAN11 17q24.2 WD-repeat protein LOC51204 17q24.2 clone HQ0477 PRO0477p LOC390806 17 similar to Hypothetical protein FLJ14668 MAP3K3 17q24.2 mitogen-activated protein kinase kinase kinase 3 MGC10986 17q24.2 hypothetical protein MGC10986 LYK5 17q24.2 protein kinase LYK5 GK001 17q24.2 GK001 protein DDX42 17q24.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 FTSJ3 17q23 FtsJ homolog 3 (E. coli) PSMC5 17q24-q25 proteasome (prosome, macropain) 26S subunit, ATPase, 5 SMARCD2 17q23-q24 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 LOC388410 17 LOC388410 CSH2 17q23.3-q24.2 chorionic somatomammotropin hormone 2 GH2 17q23 growth hormone 2 CSH1 17q23.3-q24.2 chorionic somatomammotropin hormone 1 (placental lactogen) CSHL1 17q23.3-q24.2 chorionic somatomammotropin hormone-like 1 GH1 17q24 growth hormone 1 CD79B 17q23 CD79B antigen (immunoglobulin-associated beta) SCN4A 17q23 sodium channel, voltage-gated, type IV, alpha ICAM2 17q23-q25 intercellular adhesion molecule 2 ERN1 16p12 ER to nucleus signalling 1 FLJ30999 17q24.2 hypothetical protein FLJ30999 HT008 17q24.2 uncharacterized hypothalamus protein HT008 LOC253013 17q24.2 similar to ribosomal protein L31 PECAM1 17q23 platelet/endothelial cell adhesion molecule (CD31 antigen)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunespleen   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone  highly
Epithelialbarrier/lining   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Blood/Hematopoieticplatelet
Cardiovascularendothelial cell
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • a signal sequence, an extracellular region
  • two Ig-like domains
  • a single transmembrane (1TM) segment
  • a cytoplasmic C terminus containing a positively charged aminoacid cluster in the juxtamembrane cytoplasmic domain, ERM proteins binding
  • HOMOLOGY
    Homologene
    FAMILY
  • Ig superfamily
  • CATEGORY adhesion , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • redistributed by ezrin (VIL2) as a target for killer cells
  • activating PI3K pathway leading to inhibition of apoptosis
  • having a signaling function
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for (LFA1,CD11A/CD18)
  • binding and blocking ITGB2 dependent cell adhesion
  • interacting with ICAM1 and EZR in microvillar projections under phosphatidylinositol-4,5 biphosphate regulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS