Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
Symbol ICAM1 contributors: mct - updated : 25-08-2016
HGNC name intercellular adhesion molecule 1
HGNC id 5344
Corresponding disease
FCNC1 candidiasis familial chronic mucocutaneous, 1
Location 19p13.2      Physical location : 10.381.516 - 10.397.291
Synonym name
  • Ig superfamily cell differentiation antigen CD54, 90kD, identified by antibodies RR1/1, LB-2, 7F7, 8F5, WEHI-CAMI, OKT27, F2B1.8, Myl3, 84H10
  • human rhinovirus receptor
  • major group rhinovirus receptor
  • CD54 antigen
  • cell surface glycoprotein P3.58
  • Synonym symbol(s) CD54, BB2, ICA1, P3.58, ICAM-1
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 15.78 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • promoter contains several cis-active regulatory elements including 2 Ets binding sites (EBSs) located at positions -158 and -138 relatively to the AUG, and functional cooperation between STAT1 and ETS1 to optimize ICAM1 gene transcription(
  • MAPPING cloned Y linked Y status confirmed
    Physical map
    LOC162993 19p13.2 hypothetical protein LOC162993 UBE2L4 19q13.1-q13.2 ubiquitin-conjugating enzyme E2L 4 FBXL12 19p13.2 F-box and leucine-rich repeat protein 12 PIN1 19p13.2 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 UBL5 19p13.3 ubiquitin-like 5 LOC390888 19 similar to 60S ribosomal protein L10 (QM protein homolog) OLFM2 19p13.2 olfactomedin 2 COL5A3 19p13.2 collagen, type V, alpha 3 RDH8 19p13.2-p13.3 retinol dehydrogenase 8 (all-trans) LOC388502 19 similar to Complement C3 precursor LOC388503 19 similar to Complement C3-1 LOC147740 19p13.2 similar to complement C3 protein (GPC3) precursor FLJ11286 19p13.2 hypothetical protein FLJ11286 ANGPTL6 19p13.2 angiopoietin-like 6 PPAN 19p13 peter pan homolog (Drosophila) P2RY11 19p13.2 purinergic receptor P2Y, G-protein coupled, 11 EIF3S4 19p13.2 eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa DNMT1 19p13.2 DNA (cytosine-5-)-methyltransferase 1 EDG5 19p13.2 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 LOC388504 19 LOC388504 MRPL4 19p13.2 mitochondrial ribosomal protein L4 ICAM1 19p13.3-p13.2 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor ICAM4 19p13.2-cen intercellular adhesion molecule 4, Landsteiner-Wiener blood group ICAM5 19p13.2 intercellular adhesion molecule 5, telencephalin LOC388505 MGC19604 19p13.2 similar to RIKEN cDNA B230118G17 gene RAVER1 19p13.2 RAVER1 ICAM3 19p13.3-p13.2 intercellular adhesion molecule 3 TYK2 19p13.2 tyrosine kinase 2 CDC37 19p13.2 CDC37 cell division cycle 37 homolog (S. cerevisiae) PDE4A 19p13.2 phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) KEAP1 19p13.2 kelch-like ECH-associated protein 1 EDG8 19p13.2 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 AUTL4 19p13.2 AUT-like 4, cysteine endopeptidase (S. cerevisiae) FLJ12949 19p13.2 hypothetical protein FLJ12949 CDKN2D 19p13.2 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) AP1M2 19p13.2 adaptor-related protein complex 1, mu 2 subunit CTL2 19p13.1 adaptor-related protein complex 1, mu 2 subunit ILF3 19p13 interleukin enhancer binding factor 3, 90kDa QTRT1 19p13.3 queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase) DNM2 19p13.2 dynamin 2
    TRANSCRIPTS type messenger
    text alternatively spliced isoforms that are functional, and play key roles during the progression of CNS inflammation (PMID: 20371120)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3249 55.2 532 - 2001 11390397
    - - - - - - 2010 20529672
  • also called mICAM1
  • membranous form
  • on exosomes exhibits potent immune modulatory activity
  • on exosomes was functional in leukocyte adhesion and exhibits
  • immune modulatory activity
    - - - - - - 2010 20529672
  • also called sICAM1
  • soluble form
  • cannot exert potent immune modulatory activity due to its low affinity for leukocyte function-associated antigen-1 (LFA-1) or membrane attack complex-1
  • increased levels in the serum of patients with inflammations, infections, and cancer, indicating that it may be a useful parameter for the diagnosis and evaluation of these pathologic conditions
  • plays a role in inflammation- and tumor-mediated neovascularization
  • with ICAM1, have a dual effect on bone homeostasis, increasing osteoclast activity while lowering osteoblast anabolic activity (PMID: 18979153)
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Digestivemouthtongue  highly
    Endocrinepancreas   highly
    Respiratorylung   moderately
    Urinarykidney   highly
    Visualeyeanterior segmentconjunctiva  
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    at STAGE
  • a signal sequence
  • an extracellular region with five Ig-like C2-type domains
  • a single transmembrane segment (1TM)
  • a cytoplasmic C terminus, containing a positively charged aminoacid cluster in the juxtamembrane cytoplasmic domain, ERM proteins binding
  • conjugated GlycoP
    mono polymer homomer , dimer
    interspecies homolog to rattus Icam1 (53.31 pc)
    homolog to murine Icam1 (54.25 pc)
  • immunoglobulin superfamily of adhesion proteins
  • ICAM family
  • CATEGORY adhesion , antigen
        plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • inhibiting interleukin 4 production by naive T cells
  • playing a role in cell to cell mediated immune response
  • clustering in an endothelial actin rich docking structure with VCAM1, MSN, VIL2
  • mediating leukocytes migration into sites of airway inflammation and activation of T cells
  • may be playing an important role for endothelial cell migration, through a pathway regulating endothelial nitric-oxide synthase activation and organization of the actin cytoskeleton
  • playing an essential role of with ITGB2 in mediating EPC (endothelial progenitor cells) recruitment, angiogenesis, and repair to the infarcted myocardium
  • implicated in neutrophil and monocyte-endothelial cell adhesion, processes contributing to myocardial neutrophil infiltration and microvascular coronary slow flow
  • on osteoclast precursors manifested as clusters which localized at the baso-lateral membrane
  • dynamic molecule localized in the apical membrane of the endothelium and clusters upon binding to leukocytes
  • AGER and ICAM1 are a new set of functionally linked adhesion molecules, which closely cooperate in mediating leukocyte adhesion during the acute trauma-induced inflammatory response
  • functions in leukocyte trafficking, activation, and the formation of the immunological synapse
  • with VCAM1 were critical for mesenchymal stem cell (MSC)-mediated immunosuppression
  • inducible surface glycoprotein that mediates adhesion-dependent cell-to-cell interactions
  • expressed by cardiac fibroblasts with SELE and CXC chemokines in response to proinflammatory cytokine stimulation in the infarcted myocardium
  • AGER and ICAM1 differentially regulate leukocyte adhesion in a stimulus-dependent manner
  • role of endothelial cell adhesion molecules SELP, SELE and ICAM1 in leucocyte recruitment induced by exogenous methylglyoxal in diabetes
  • RAC1 is required for ICAM1 clustering, whereas RHOG controls membrane protrusion formation
  • functions to enhance the strength of antigenic stimulation, extend the duration of contact with antigen-presenting cells, and augment cytokine signals, which are all factors that influence peripheral CD8 T-cell differentiation
  • potential dual roles in both promoting the decay of effector responses and programming the sensitivity of memory CD8 T cells to secondary stimuli
  • CELLULAR PROCESS cell life
    cell communication
    a component
  • dimer with ITGAL
    small molecule
  • ligand for ITGB2 (CD11A/CD18)
  • interacting with ezrin, EZR and ICAM2 in microvillar projections under phosphatidylinositol-4,5 biphosphate regulation
  • interactions both within the host and between the host and a number of pathogenes
  • interacting with AGER
  • interacting with IFI16 (mediates ICAM1 stimulation by TNF-alpha through the NF-kappaB pathway, thus reinforcing the role of the IFI16 molecule in the inflammation process)
  • interacting with FLNB (filamin B is required for the lateral mobility of ICAM1 and for ICAM1-induced transmigration of leukocytes)
  • SVEP1 and SRPX2 seemed to act as regulators of ICAM1 and E-selectin shedding and influence the expression of membrane bound adhesion molecules
  • associations at the PNPLA3, RELA, and SH2B3 loci
  • thrombin (thrombin binding region in the sixth EGF like repeat)THBD and ICAM1 were induced with MIF addition in a dose-dependent and time-dependent manner
  • upon clustering of ICAM1, the Rho-guanine nucleotide exchange factor TRIO activates RAC1, prior to activating RHOG, in a filamin-dependent manner
  • ICAM1 and VCAM1, as reflecting endothelial dysfunction biomarkers, play key roles at the early stage of inflammatory response to facilitate leukocytes adhesion and transmigration in vascular endothelial cells
  • ITLN1 inhibition of TNF-induced expression of VCAM1 and ICAM1 is mediated by its down-regulation of ERK/NFKB signaling pathway
  • ITGAL/ICAM1-dependent interactions between T cells and Dendritic cells play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes
  • HMGB1 promotes an inflammatory response by inducing the expression of ICAM1 and P-selectin via AGER-mediated stimulation of the endoplasmic reticulum stress pathway
  • CLOCK is a positive regulator of ICAM1, and promotes the adhesion of mononuclear cells to endothelial cells
  • increased the cell migration and expression of intercellular adhesion molecule-1 (ICAM1) in human osteosarcoma cells
  • APOM suppressed TNF-induced expression of ICAM1 and VCAM1 through inhibiting the activity of NFKB1
  • NSUN2 upregulates the expression of ICAM1 by methylating ICAM1 mRNA, and this regulatory process impacts on vascular inflammation and allograft arteriosclerosis
  • role of KDM7A in ICAM1 protein stabilization
  • endothelial cell PTPN11 negatively regulates neutrophil adhesion and promotes transmigration by enhancing ICAM1-CDH5 interaction
  • CNOT1 provides a platform for the recruitment of TTP and CNOT7, and is involved in TTP&
  • 8209;mediated ICAM1 and IL8 mRNA decay
    cell & other
    induced by upregulated by cytokines
    Other regulated in T cells by phosphotyrosyl phosphatase activity through NFKappaB, ETS and STAT1 dependent signaling pathway
    ubiquitinated and downregulated by MARCH9
    ICAM1 clustering is regulated in an inside-out fashion through the actin cytoskeleton
    IL1A regulates CXCL1, CXCL10, and ICAM1 in network form in oral keratinocytes
    corresponding disease(s) FCNC1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    during angiogenesis
    constitutional     --over  
    in Alzheimer disease
    tumoral     --low  
    in primary myeloma cells unexpectedly showed constitutively lower expressions than normal bone marrow (BM) plasma cells
    constitutional     --over  
    increased leucocyte adhesion
    constitutional     --over  
    in preeclamptic placenta
    constitutional     --low  
    in N-glycosylation-deficient cells
  • to multiple sclerosis susceptibility
  • to type I diabetes
  • to Behcet's disease
  • to ulcerative colitis and Crohn
  • some allele(s) predisposing to cerebral malaria
  • to asthma
  • Variant & Polymorphism SNP , other
  • G/R241 associated with Behcet's disease
  • E/E469 associated with ulcerative colitis and Crohn
  • SNP 241G>A and 469G>A associated with reduced risk for asthma
  • Candidate gene for FCNC1
  • can be a useful cellular hypoglycosylation biomarker
  • could be a useful hypoglycosylation biomarker to assess gene complementation of CDG-1 patient cells and to monitor improved glycosylation in response to therapeutic drugs
  • Therapy target
    important potential therapeutic target in myocardial infarction
    disrupting ICAM-1 interactions may represent a unique therapeutic target for bolstering immunity in patients with chronic infection
  • abortive responses and a failure to form a memory T-cell compartment in Icam-1–deficient mice following peptide or protein immunization