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FLASH GENE
Symbol IBSP contributors: mct - updated : 13-10-2014
HGNC name integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)
HGNC id 5341
Location 4q22.1      Physical location : 88.720.701 - 88.733.599
Synonym name bone sialoprotein II
Synonym symbol(s) BSP, NSP, ISIAL, BSP-II, SP-II
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text SIBLINGs share many common features, such as their tandem gene location
STRUCTURE 12.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • FGF2 increases IBSP transcription by targeting the FRE and AP1 elements in the proximal promoter of the human IBSP gene
  • MAPPING cloned Y linked Y status confirmed
    Physical map
    DKFZP564B1162 4q22.1 hypothetical protein DKFZp564B1162 MAPK10 4q21-q22 mitogen-activated protein kinase 10 PTPN13 4q21.3 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) SOAT 4q22.1 sodium-dependent organic anion transporter MGC26744 4q22.1 hypothetical protein MGC26744 LOC260422 4q21.3 actin related protein 2/3 complex subunit 1A pseudogene LOC389210 4 similar to hypothetical protein LOC391676 4 similar to Synaptic glycoprotein SC2 MLLT2 4q21 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 KLHL8 4q22.1 kelch-like 8 (Drosophila) GAPDL4 4pter-p16.2 glyceraldehyde-3-phosphate dehydrogenase-like 4 SCDR9 4q22.1 short-chain dehydrogenase/reductase 9 DHRS8 4q22.1 dehydrogenase/reductase (SDR family) member 8 NUDT9 4q21.3 nudix (nucleoside diphosphate linked moiety X)-type motif 9 SPARCL1 4q27 SPARC-like 1 (mast9, hevin) DSPP 4q21.3 dentin sialophosphoprotein DMP1 4q21.2-q21.3 dentin matrix acidic phosphoprotein LOC391677 4 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein IBSP 4q21-q25 integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) MEPE 4q21.1 matrix, extracellular phosphoglycoprotein with ASARM motif (bone) HSPCP1 4q21-q25 heat shock 90kDa protein 1, beta pseudogene 1 SPP1 4q21-q25 secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) PKD2 4q22 polycystic kidney disease 2 (autosomal dominant) ABCG2 4q22 ATP-binding cassette, sub-family G (WHITE), member 2 DKFZp761G058 4q22.1 hypothetical protein DKFZp761G058 CEB1 4q22.1-q23 hypothetical protein DKFZp761G058 MGC14156 4q22.1 hypothetical protein MGC14156 HERC3 4q21 hect domain and RLD 3 DRLM FAM13A1 4q21 family with sequence similarity 13, member A1 LOC389211 4 similar to expressed sequence AW060714 TIGD2 4q21.3 tigger transposable element derived 2 LOC285513 4q22.1 hypothetical protein LOC285513
    regionally located closely linked to SPP1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1595 - 317 - 2003 13679028
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral  
    Connectivecartilage   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveodontoblast Homo sapiensFetal
    Skeletonosteoblast Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text cochlea
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple phosphorylation sites
  • disulfide-free flexible hydrophilic structures
  • presence of the integrin-binding tripeptide, arginine-glycine-aspartate (RGD)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ibsp
    Homologene
    FAMILY SIBLING family (small integrin binding ligang N linked glycoprotein)
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text bone matrix protein
    basic FUNCTION
  • mediating cell attachment through an RGD sequence that recognizes the vitronectin receptor
  • involved in bone mineralization and remodeling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , ossification
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • MSX2, RUNX2 and SMADl transcription factors appear to be key regulators of IL11 effects on IBSP transcription
  • KDM6B plays important roles in osteoblast differentiation and regulates the expressions of IBSP and BGLAP via transcription factors RUNX2 and SP7
  • ESR1 stimulates likely IBSP gene transcription in a ligand-independent manner by targeting the CRE and AP1/GRE elements in the IBSP gene promoter
  • cell & other binding to hydroxyapatite
    REGULATION
    Other regulated by RUNX2 in osteoblasts
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    during early bone formation and may play a role in primary mineralization of bone
    constitutional     --low  
    affects both osteoclast formation and activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • adult Ibsp-knockout mice (BSP-/-) display shorter stature, lower bone turnover and higher trabecular bone mass than wild type, the latter resulting from impaired bone resorption