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FLASH GENE
Symbol IBSP contributors: mct - updated : 13-10-2014
HGNC name integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)
HGNC id 5341
Location 4q22.1      Physical location : 88.720.701 - 88.733.599
Synonym name bone sialoprotein II
Synonym symbol(s) BSP, NSP, ISIAL, BSP-II, SP-II
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text SIBLINGs share many common features, such as their tandem gene location
STRUCTURE 12.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • FGF2 increases IBSP transcription by targeting the FRE and AP1 elements in the proximal promoter of the human IBSP gene
  • MAPPING cloned Y linked Y status confirmed
    regionally located closely linked to SPP1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1595 - 317 - 2003 13679028
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral  
    Connectivecartilage   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveodontoblast Homo sapiensFetal
    Skeletonosteoblast Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text cochlea
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple phosphorylation sites
  • disulfide-free flexible hydrophilic structures
  • presence of the integrin-binding tripeptide, arginine-glycine-aspartate (RGD)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ibsp
    Homologene
    FAMILY SIBLING family (small integrin binding ligang N linked glycoprotein)
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text bone matrix protein
    basic FUNCTION
  • mediating cell attachment through an RGD sequence that recognizes the vitronectin receptor
  • involved in bone mineralization and remodeling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , ossification
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • MSX2, RUNX2 and SMADl transcription factors appear to be key regulators of IL11 effects on IBSP transcription
  • KDM6B plays important roles in osteoblast differentiation and regulates the expressions of IBSP and BGLAP via transcription factors RUNX2 and SP7
  • ESR1 stimulates likely IBSP gene transcription in a ligand-independent manner by targeting the CRE and AP1/GRE elements in the IBSP gene promoter
  • cell & other binding to hydroxyapatite
    REGULATION
    Other regulated by RUNX2 in osteoblasts
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    during early bone formation and may play a role in primary mineralization of bone
    constitutional     --low  
    affects both osteoclast formation and activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • adult Ibsp-knockout mice (BSP-/-) display shorter stature, lower bone turnover and higher trabecular bone mass than wild type, the latter resulting from impaired bone resorption