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FLASH GENE

Symbol

IARS2

contributors: - updated : 05-09-2006

HGNC name	isoleucine-tRNA synthetase 2, mitochondrial
HGNC id	29685

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q41      Physical location : 220.267.454 - 220.321.376
Synonym name	isoleucine-tRNA ligase
Synonym symbol(s)	FLJ10326
EC.number	6.1.1.5

DNA

TYPE	functioning gene
STRUCTURE	53.00 kb     23 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         liver           pharynx         Endocrine parathyroid         Lymphoid/Immune lymph node         Reproductive female system breast mammary gland

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Iars2 (83.4pc)
	homolog to chicken IARS2 (72.4pc)

Homologene

FAMILY

class-I aminoacyl-tRNA synthetase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
text	nuclear gene for a mitochondrial protein

basic FUNCTION

aminoacyl-tRNA synthetase activity

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

protein

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding, nucleotide,
	ATP binding
	ion Zn2+ binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS