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FLASH GENE
Symbol HYOU1 contributors: - updated : 09-01-2006
HGNC name hypoxia up-regulated 1
HGNC id 16931
Location 11q23.1-q23.3      Physical location : 118.914.895 - 118.927.925
Synonym name oxygen regulated protein (150kD)
Synonym symbol(s) ORP150
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     27 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
cytosine-phosphate-guanine/HTF
Binding site   transcription factor
text structure
  • Sp1 binding sites
  • ERSE like sequence
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselsaorta   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth   
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    Nervousastrocyte
    cell lineage
    cell lines breast cancer, thyroid carcinoma, pancreatic carcinoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal domain
  • a chain with ATP binding sites
  • nine glycosylation sites
  • one site preventing secretion from endoplasmic reticulum
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to Drosophila EG:25E8.1
    homolog to C.elegans T14G8.3
    Homologene
    FAMILY heat shock protein 70 family
    CATEGORY chaperone/stress , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • having a cytoprotective role in hypoxia-induced cellular perturbations
  • CELLULAR PROCESS cell life, antiapoptosis
    protein, post translation, folding
    protein, post translation, targeting
    PHYSIOLOGICAL PROCESS nervous system
    text wound healing
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
    cell & other
    REGULATION
    induced by hypoxia,tunicamycin,2-desoxyglucose,oxidized LDL
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in atherosclerotic plaques
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS