basic FUNCTION
| acting as a ligase |
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mediating ubiquitination and subsequent proteasomal degradation of target proteins |
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regulating apoptosis by catalyzing the polyubiquitination and degradation of MCL1 |
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ubiquitinating core histones including H1, H2A, H2B, H3 and H4 |
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being essential for proliferation of a subset of tumor cells, and negative regulator of TP53 during the colorectal carcinoma progression through the ubiquitination pathway mediated by the HECT domain |
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implicated in TP53-associated regulation of the neuronal cell cycle |
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operates upstream of the MYCN-DLL3-NOTCH1 pathway to control neural stem cell activity and promote neurogenesis |
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having a role in regulating Berg-mann glia differentiation and this ubiquitin ligase orchestrates the programming of the neural progenitors that give rise to neurons and glia in the cerebellum |
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required for PMAIP1-induced MCL1 degradation |
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involvement of HUWE1 in the ubiquitination and proteasomal degradation of MYOD1 |
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dosage-sensitive gene for which a 2-fold increase in expression results in mild to moderate intellectual disability in males |
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HUWE1 and TRIP12 function likely in parallel during ubiquitin fusion degradation (UFD) |
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HUWE1 is a novel player involved in regulating ERK1/2 signal transmission through the SHOC2 scaffold complex |
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HUWE1 and NEDD4, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters |
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acts as an intestinal tumor suppressor by regulation of the intestinal stem cell niche |
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HECT domain containing ubiquitin ligase implicated in neurogenesis, spermatogenesis and cancer development |
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is a bona fide tumour suppressor gene in the intestinal epithelium |
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role of HUWE1 in orchestrating the physiological DNA damage response in the male germline that contributes to the establishment and maintenance of spermatogonia |
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regulates essential processes such as genome integrity maintenance |
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critical role as a modulator of the DNA damage response pathway in the earliest steps of spermatogonial differentiation |
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HUWE1 is a key inducing factor in AMBRA1-mediated mitophagy, a process that takes place independently of the main mitophagy receptors |
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HUWE1 is required for a wide array of important functions in cell biology |
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regulates effectors of DNA replication and genotoxic stress tolerance |