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FLASH GENE
Symbol HUS1B contributors: mct/npt - updated : 28-01-2009
HGNC name HUS1 checkpoint homolog b (S. pombe)
HGNC id 16485
Location 6p25.3      Physical location : 655.939 - 656.964
Synonym name
  • HUS1 (S.Pombe) checkpoint homolog
  • checkpoint protein HUS1B
  • Synonym symbol(s) MGC126746, MGC126748, RP11-532F6.1
    DNA
    TYPE functioning gene
    STRUCTURE 1.03 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389451 6 LOC389451 HLA-DRB9 6p21.3 major histocompatibility complex, class II, DR beta 9 (pseudogene) LOC391863 6 similar to Olfactory receptor 4F3 HLA-DRB5 6p21.3 major histocompatibility complex, class II, DR beta 5 LOC389356 6 similar to bA476I15.3 (novel protein similar to septin) HLA-DRB6 6p21.3 major histocompatibility complex, class II, DR beta 6 (pseudogene) HLA-DRB1 6p21.3 major histocompatibility complex, class II, DR beta 1 C6orf35 6q25.3 chromosome 6 open reading frame 35 LOC389357 6 LOC389357 DUSP22 6p24.3 dual specificity phosphatase 22 IRF4 6p25-p23 interferon regulatory factor 4 SEC5 LOC391990 6 similar to serine palmitoyltransferase, long chain base subunit 2; serine palmitoyltransferase, subunit II HUS1B 6p25.3 HUS1 checkpoint homolog b (S. pombe) LOC340177 6q27 hypothetical LOC340177 LOC389452 6 LOC389452 LOC391991 6 similar to lysR-like transcriptional regulator LOC391992 6 similar to putative heavy metal transporter LOC391993 6 similar to F22G5.20 LOC391994 6 similar to Hypothetical protein FLJ30525 LOC221768 6p25.3 similar to ENSANGP00000010305 FOXQ1 6p25-p23 forkhead box Q1 LOC389358 6 LOC389358 FOXF2 6p25.3 forkhead box F2 LOC221766 6p25.3 hypothetical LOC221766 LOC389359 6 LOC389359 LOC389360 6 LOC389360 LOC389361 6 LOC389361 FOXC1 6p25 forkhead box C1 GMDS 6p25 GDP-mannose 4,6-dehydratase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1026 31 278 - Mungall (2003)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies paralog to HUS1
    Homologene
    FAMILY
  • HUS1 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • playing a role in regulating cell cycle checkpoints and genomic integrity
  • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • HUS1B-RAD1-RAD9A in a PCNA-like structure
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RAD9A and RAD9B (these proteins can combinatorially assemble into distinct 9-1-1 clamps that may have distinct biological functions) (Dufault 2003)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    induce cell death
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS