Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HUS1 contributors: mct/npt/pgu - updated : 28-01-2009
HGNC name HUS1 checkpoint homolog (S. pombe)
HGNC id 5309
Location 7p12.3      Physical location : 48.003.782 - 48.019.246
Synonym name
  • cell cycle G2 checkpoint control gene
  • hus1+-like protein
  • DNA
    TYPE functioning gene
    STRUCTURE 15.50 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - D7S1896 - D7S806 - HUS1 - D7S1600 - D7S2712 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2143 31.7 280 - 2008 18794804
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunespleen   highly
    Reproductivemale systemtestis  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to yeast S.pombe Hos1
    homolog to murine Hus1
    Homologene
    FAMILY
  • HUS1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in cell cycle G2 checkpoint control
  • involved in DNA damage checkpoint regulation, which is required for the maintenance of genomic stability
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    text DNA damage checkpoint
    PATHWAY
    metabolism
    signaling
    a component
  • forming DNA damage-responsive protein complex with RAD1 and RAD9A, heterotrimeric complex (Rad9A-Rad1-Hus1 cell cycle checkpoint complex plays a key role in the DNA damage response
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with itself and the C terminus of RAD1
  • interacting with TDG
  • interacting with COPS5 (mediates protein degradation of the Rad9A-Rad1-Hus1 checkpoint complex)
  • DNA2 shows partial redundancy for the replication checkpoint with checkpoint initiators RAD9-RAD1-HUS1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    sensitizes cells to etoposide-induced apoptosis not only by inducing BCL2L11 and BBC3 expressions but also by releasing RAD9A into the cytosol to augment mitochondrial apoptosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene prognostic markers in epithelial ovarian tumors
    Marker
    Therapy target
    ANIMAL & CELL MODELS