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FLASH GENE
Symbol HUS1 contributors: mct/npt/pgu - updated : 28-01-2009
HGNC name HUS1 checkpoint homolog (S. pombe)
HGNC id 5309
Location 7p12.3      Physical location : 48.003.782 - 48.019.246
Synonym name
  • cell cycle G2 checkpoint control gene
  • hus1+-like protein
  • DNA
    TYPE functioning gene
    STRUCTURE 15.50 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - D7S1896 - D7S806 - HUS1 - D7S1600 - D7S2712 - cen
    Physical map
    MRPL42P4 7p12.3 similar to KIAA1285 protein LOC346472 7p12.3 similar to Splicing factor, arginine/serine-rich, 46kD TENS1 7p12.3 tensin-like SH2 domain-containing 1 MGC16075 7p12.3 hypothetical protein MGC16075 PKD1L1 7p13-p12 polycystic kidney disease 1 like 1 FLJ21075 7p12.3 hypothetical protein FLJ21075 HUS1 7p13-p12 HUS1 checkpoint homolog (S. pombe) MGC33329 7p12.3 hypothetical protein MGC33329 LOC136288 7p12.3 hypothetical protein LOC136288 UPP1 7p12.3 uridine phosphorylase 1 LOC393062 7 similar to Mtr3 (mRNA transport regulator 3)-homolog; Mtr3 (mRNA transport regulator 3)-homolog (yeast) MGC16075 7p12.3 hypothetical protein MGC16075 PKD1L1 7p13-p12 polycystic kidney disease 1 like 1 FLJ21075 7p12.3 hypothetical protein FLJ21075 ABCA13 7p12.3 ATP binding cassette gene, sub-family A (ABC1), member 13 LOC393063 7 similar to 60S ribosomal protein L32 C7orf33 7q36.1 chromosome 7 open reading frame 33 LOC393064 7 similar to Huntingtin interacting protein K HUS1 7p13-p12 HUS1 checkpoint homolog (S. pombe) CUL1 7q35-q36 cullin 1 MGC33329 7p12.3 hypothetical protein MGC33329 LOC136288 7p12.3 hypothetical protein LOC136288 UPP1 7p12.3 uridine phosphorylase 1 LOC392834 7 similar to Enhancer of zeste homolog 2 (ENX-1) ABCA13 7p12.3 ATP binding cassette gene, sub-family A (ABC1), member 13 RNY5 7q36 RNA, Y5 small cytoplasmic (associated with Ro protein) ERP70 7q35 protein disulfide isomerase related protein (calcium-binding protein, intestinal-related) DKFZp762I137 7q36.1 hypothetical protein DKFZp762I137 LOC155054 7q36.1 hypothetical protein LOC155054 ZNF398 7q36.1 zinc finger protein 398 ZNF282 7q35-q36 zinc finger protein 282 LOC392669 7 hypothetical gene supported by BC028690 ZNF212 7q36.1 zinc finger protein 212 LOC392835 7 similar to KIAA1285 protein LOC392897 7 similar to GDP dissociation inhibitor isoform 2; GDI-2 LOC393065 7 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 MGC26484 7p12.3 hypothetical protein MGC26484 KIAA1285 7q36.1 hypothetical protein MGC26484 FLJ31413 7q36.1 hypothetical protein FLJ31413 LOC393066 7 similar to KIAA1285 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2143 31.7 280 - 2008 18794804
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunespleen   highly
    Reproductivemale systemtestis  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to yeast S.pombe Hos1
    homolog to murine Hus1
    Homologene
    FAMILY
  • HUS1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in cell cycle G2 checkpoint control
  • involved in DNA damage checkpoint regulation, which is required for the maintenance of genomic stability
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    text DNA damage checkpoint
    PATHWAY
    metabolism
    signaling
    a component
  • forming DNA damage-responsive protein complex with RAD1 and RAD9A, heterotrimeric complex (Rad9A-Rad1-Hus1 cell cycle checkpoint complex plays a key role in the DNA damage response
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with itself and the C terminus of RAD1
  • interacting with TDG
  • interacting with COPS5 (mediates protein degradation of the Rad9A-Rad1-Hus1 checkpoint complex)
  • DNA2 shows partial redundancy for the replication checkpoint with checkpoint initiators RAD9-RAD1-HUS1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    sensitizes cells to etoposide-induced apoptosis not only by inducing BCL2L11 and BBC3 expressions but also by releasing RAD9A into the cytosol to augment mitochondrial apoptosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene prognostic markers in epithelial ovarian tumors
    Marker
    Therapy target
    ANIMAL & CELL MODELS