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FLASH GENE
Symbol HTRA3 contributors: mct - updated : 27-06-2017
HGNC name HtrA serine peptidase 3
HGNC id 30406
Location 4p16.1      Physical location : 8.271.491 - 8.308.830
Synonym name
  • pregnancy related serine protease, mouse homolog
  • high- temperature requirement factor A3
  • Synonym symbol(s) PRSP, Tasp
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    STRUCTURE 37.35 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    AFAP 4p16 actin filament associated protein MGC10981 4p16.1 hypothetical protein MGC10981 LOC389199 4 hypothetical gene supported by BC031673 ABLIM2 4p16-p15 actin binding LIM protein 2 LOC391618 4 hypothetical gene supported by NM_003875 FLJ20356 HTRA3 4p16.1 serine protease HTRA3 ACOX3 4p15.3 acyl-Coenzyme A oxidase 3, pristanoyl FLJ35725 4p16.1 hypothetical protein FLJ35725 FLJ12891 4p16.1 hypothetical protein FLJ12891 GPR78 4p16.1 G protein-coupled receptor 78 CPZ 4p16 carboxypeptidase Z LOC391619 4 similar to ubiquitin-specific protease 17-like protein LOC391620 4 similar to ubiquitin-specific protease 17-like protein LOC391621 4 similar to ubiquitin-specific protease 17-like protein LOC391622 4 similar to ubiquitin-specific protease 17-like protein LOC391623 4 similar to ubiquitin-specific protease 17-like protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1953 38 357 - 2007 17962403
  • HTRA3S, lacking the C-terminal PDZ domain, which is substituted by a stretch of 7 C-terminal amino acid, unique for this isoform
  • encoding by exons 1 through 7
  • 9 splicing 2586 48.5 453 - 2007 17962403
  • HTRA3L
  • encoding by exons 1 through 6 plus exons 8 through 10
  • in late-onset preeclampsia, significantly higher levels of HTRA3L
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestivesalivary gland   highly
    Hearing/Equilibriumear   moderately
    Lymphoid/Immunelymph node   moderately
    Nervousbrain    
    Reproductivefemale systembreastmammary gland moderately
     female systemplacenta  highly Homo sapiens
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 17 aa signal peptide
  • an IGFBP N-terminal domain not required for proteolytic activity,
  • a kazal-like domain
  • a central serine protease domain
  • a C-terminal PDZ domain
  • HOMOLOGY
    interspecies homolog to rattus Htra3 (92.3 pc)
    homolog to murine Htra3 (92.7 pc)
    Homologene
    FAMILY
  • peptidase S1B family, HTRA family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a serine-type endopeptidase
  • involved in placentation
  • is an inhibitor of trophoblast invasion during placental development
  • decidual HTRA3 negatively regulates trophoblast invasion.
  • is important for placental development and cancer progression
  • HTRA1 and HTRA3 are crucial for trophoblast-decidual cell interaction in the control of trophoblast invasion
  • involved in the pathogenesis of ovarian cancer
  • HTRA1, HTRA2, HTRA3, HTRA4 function as important modulators of many physiological processes, including maintenance of mitochondrial homeostasis, cell signaling and apoptosis
  • HTRA3 protease is a proapoptotic protein, involved in embryo implantation and oncogenesis
  • CELLULAR PROCESS cell life, proliferation/growth
    protein, degradation
    PHYSIOLOGICAL PROCESS
    text
  • regulation of cell growth
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • decidua-secreted HTRA1 and HTRA3 antagonize HTRA4-mediated trophoblast invasion
  • cell & other
    REGULATION
    activated by by removal of its N-terminal domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in endometrial cancer
    constitutional     --over  
    in late-onset preeclampsia
    tumoral     --low  
    not correlated with peritoneal metastasis of epithelial ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential diagnostic marker for early detection of preeclampsia
  • Therapy target
    ANIMAL & CELL MODELS