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FLASH GENE
Symbol HTR4 contributors: - updated : 05-01-2007
HGNC name 5-hydroxytryptamine (serotonin) receptor 4
HGNC id 5299
Location 5q31-q33      Physical location : 147.830.594 - 148.033.739
Synonym symbol(s) SH4, 5-HT4R , 5-HT4
DNA
TYPE functioning gene
STRUCTURE 203.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • binding sites for Sp1, Ap2, Ap4, GATA
  • regulatory sequence in exon 1
  • major transcription start site of the h5-HT4 receptor gene is located at -3185 bp relative to the first ATG codon
  • in addition, a 1.2 kb promoter fragment which drives the transcription of the 5-HT4 receptor was characterized
  • complex regulation of the h5-HT4 receptor gene expression involving distinct promoters and non-coding exons
    • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1481 - 387 - Li
    - - 2981 - 388 - Li
    - - 1355 - 360 - Li
    - - 3023 - 402 - Li
    - - 3101 - 428 - Li
    - - 1379 - 359 - Li
    - - 1557 - 378 - Li
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheartatrium   
    Digestiveintestinesmall intestineileum  
     intestinelarge intestinecolon  
     stomach    
    Nervousnerve    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		ligand ion channel with four transmembrane segments
    HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • activating adenylate cyclase
  • biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by G proteins that stimulate adenylate cyclase
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS