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FLASH GENE
Symbol HTR4 contributors: - updated : 05-01-2007
HGNC name 5-hydroxytryptamine (serotonin) receptor 4
HGNC id 5299
Location 5q31-q33      Physical location : 147.830.594 - 148.033.739
Synonym symbol(s) SH4, 5-HT4R , 5-HT4
DNA
TYPE functioning gene
STRUCTURE 203.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • binding sites for Sp1, Ap2, Ap4, GATA
  • regulatory sequence in exon 1
  • major transcription start site of the h5-HT4 receptor gene is located at -3185 bp relative to the first ATG codon
  • in addition, a 1.2 kb promoter fragment which drives the transcription of the 5-HT4 receptor was characterized
  • complex regulation of the h5-HT4 receptor gene expression involving distinct promoters and non-coding exons
  • MAPPING cloned Y linked   status provisional
    Physical map
    MGC22688 5q32 hypothetical protein MGC22688 DPYSL3 5q32 dihydropyrimidinase-like 3 KIAA0555 5q32 dihydropyrimidinase-like 3 SPINK1 5q31 serine protease inhibitor, Kazal type 1 LOC391838 5 similar to low affinity N-formyl peptide receptor SCGB3A2 5q32 secretoglobin, family 3A, member 2 LOC389336 5 similar to AVLV472 LOC391839 5 similar to elongation factor 1 gamma SPINK5 5q32 serine protease inhibitor, Kazal type, 5 LOC340060 5q33.1 similar to alpha-5 collagen ECG2 5q33.1 similar to alpha-5 collagen FLJ13962 5q33.1 hypothetical protein FLJ13962 SP329 5q33.1 hypothetical protein SP329 HTR4 5q31-q33 5-hydroxytryptamine (serotonin) receptor 4 ADRB2 5q31.3 adrenergic, beta-2-, receptor, surface KIAA1985 LOC255187 5q33.1 hypothetical LOC255187 KIAA0843 FLJ36748 5q33.1 hypothetical protein FLJ36748 GRPEL2 5q33.1 GrpE-like 2, mitochondrial (E. coli) MGC3265 5q33.1 hypothetical protein MGC3265 IL17B 5q32-34 interleukin 17B CSNK1A1 13q13 casein kinase 1, alpha 1 LOC389337 5 similar to hypothetical protein 4933429F08 PERC 5q33.1 similar to hypothetical protein 4933429F08 PDE6A 5q31.3 phosphodiesterase 6A, cGMP-specific, rod, alpha SLC26A2 5q31.3 solute carrier family 26 (sulfate transporter), member 2 TIGD6 5q32 tigger transposable element derived 6 RPS20P4 5q33-qter ribosomal protein S20 pseudogene 4 CSF1R 5q31.3 colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1481 - 387 - Li
    - - 2981 - 388 - Li
    - - 1355 - 360 - Li
    - - 3023 - 402 - Li
    - - 3101 - 428 - Li
    - - 1379 - 359 - Li
    - - 1557 - 378 - Li
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheartatrium   
    Digestiveintestinesmall intestineileum  
     intestinelarge intestinecolon  
     stomach    
    Nervousnerve    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    ligand ion channel with four transmembrane segments
    HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • activating adenylate cyclase
  • biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by G proteins that stimulate adenylate cyclase
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS