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FLASH GENE
Symbol HTR3C contributors: mct/npt - updated : 07-11-2009
HGNC name 5-hydroxytryptamine (serotonin) receptor 3, family member C
HGNC id 24003
Location 3q27.1      Physical location : 183.770.834 - 183.778.459
Synonym name
  • 5-hydroxytryptamine receptor 3 subunit C
  • serotonin receptor 3C
  • DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with HTR3E and HTR3D
    STRUCTURE 7.63 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1745 - 447 - Karnovsky (2003)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
     spinal cord    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • cation-selective ion channels of the Cys-loop transmitter-gated ion channel superfamily
  • ligand-gated ionic channel family
  • CATEGORY signaling neurotransmitter , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in fast depolarizing responses in neurons after activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component with HTR3E, and HTR3C, are able to form heteromeric 5-HT(3) receptors, which exhibit quantitatively different functional properties compared with homomeric 5-HT(3A) receptors (Niesler 2007)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism (ASD)
    Variant & Polymorphism SNP two non-synonymous SNPs in HTR3C, rs6766410 and rs6807362 associated to autism (Rehnström 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS