Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HTR2C contributors: mct - updated : 18-08-2010
HGNC name 5-hydroxytryptamine (serotonin) receptor 2C
HGNC id 5295
Location Xq23      Physical location : 113.818.550 - 114.144.624
Synonym name
  • serotonin receptor 2C
  • 5-hydroxytryptamine receptor 1C
    • Synonym symbol(s) HT2C, HTR1C, 5-HT2C, 5-HTR2C, 5-HT-1C
    DNA
    TYPE functioning gene
    STRUCTURE 358.68 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure
  • alternative exon Vb is regulated by expressing a C/D box snoRNA, SNORD115 (Kishore 2010)
    • MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4774 51.8 458 - McGrew (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainbasal nucleicaudate nucleus  
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
    • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • activating the phosphatidylinositol cycle
  • mediating its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger
    • system
  • HTR2B, HTR2C receptors on motoneurons become constitutively active after injury and ultimately contribute to recovery of motoneuron function and emergence of spasms
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HTR2A, HTR2B, HTR2C are implicated as being critical for induction of PTHLH and RUNX2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to obesity and increased BMI
  • to metabolic syndrome in patients with schizophrenia
    • Variant & Polymorphism SNP
  • increasing the risk of obesity
  • HTR2C:c.1-142948(GT)n associated with an increased risk of the metabolic syndrome in patients with schizophrenia (Mulder 2007)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse model lacking MBII-52 snoRNAs shows differences in pre-mRNA processing of the serotonin receptor (Kishore 2010)