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FLASH GENE
Symbol HTR2C contributors: mct - updated : 18-08-2010
HGNC name 5-hydroxytryptamine (serotonin) receptor 2C
HGNC id 5295
Location Xq23      Physical location : 113.818.550 - 114.144.624
Synonym name
  • serotonin receptor 2C
  • 5-hydroxytryptamine receptor 1C
  • Synonym symbol(s) HT2C, HTR1C, 5-HT2C, 5-HTR2C, 5-HT-1C
    DNA
    TYPE functioning gene
    STRUCTURE 358.68 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure
  • alternative exon Vb is regulated by expressing a C/D box snoRNA, SNORD115 (Kishore 2010)
  • MAPPING cloned Y linked Y status confirmed
    Physical map
    PAK3 Xq22.33-q23 p21 (CDKN1A)-activated kinase 3 CAPN6 Xq23 calpain 6 DCX Xq22.3-q23 doublecortex; lissencephaly, X-linked (doublecortin) LOC392521 X similar to High mobility group protein 1-like 10 (HMG-1L10) LOC389880 X hypothetical gene supported by AB076839; NM_001417 LOC392522 X similar to 60S ribosomal protein L18a MDS031 Xq23 uncharacterized hematopoietic stem/progenitor cells protein MDS031 FLJ23018 Xq23 hypothetical protein FLJ23018 TRPC5 Xq23-q24 transient receptor potential cation channel, subfamily C, member 5 LOC389881 X similar to hypothetical protein FLJ13646 LOC340595 Xq23 similar to zinc finger, CCHC domain containing 5 LHFPL1 Xq23 lipoma HMGIC fusion partner-like 1 LOC203510 Xq23 similar to high mobility group protein homolog HMG4 AMOT Xq23 angiomotin LOC139466 Xq23 peptidyl prolyl isomerase H (cyclophilin H) pseudogene LOC286528 Xq24 similar to HSPC182 protein HTR2C Xq24 5-hydroxytryptamine (serotonin) receptor 2C IL13RA2 Xq24 interleukin 13 receptor, alpha 2 LOC392524 X similar to YAP1 protein KIAA1495 Xq24 KIAA1495 protein TMSL7 X thymosin-like 7 FLJ40249 Xq24 hypothetical protein FLJ40249 HOM-TES-85 Xq24 HOM-TES-85 tumor antigen PLS3 Xq24 plastin 3 (T isoform) ASSP5 Xq22-q26 argininosuccinate synthetase pseudogene 5 LOC136337 Xq24 similar to elongation factor 1 gamma LOC222019 Xq24 hypothetical gene supported by BC022340; L76416 LOC392525 X similar to Aldo-keto reductase family 1, member B1 LOC286533 Xq24 similar to apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; API5-like 1 AGTR2 Xq22-q23 angiotensin II receptor, type 2 SLC6A14 Xq23-q24 solute carrier family 6 (neurotransmitter transporter), member 14 LOC203413 Xq24 hypothetical LOC203413 LOC392526 X similar to Serine/threonine-protein kinase PRP4 homolog (PRP4 pre-mRNA processing factor 4 homolog) (Pre-mRNA protein kinase) LOC392527 X similar to protein phosphatase 2A inhibitor-2 I-2PP2A KIAA1309 Xq23-q24 KIAA1309
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4774 51.8 458 - McGrew (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainbasal nucleicaudate nucleus  
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • activating the phosphatidylinositol cycle
  • mediating its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger
  • system
  • HTR2B, HTR2C receptors on motoneurons become constitutively active after injury and ultimately contribute to recovery of motoneuron function and emergence of spasms
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HTR2A, HTR2B, HTR2C are implicated as being critical for induction of PTHLH and RUNX2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to obesity and increased BMI
  • to metabolic syndrome in patients with schizophrenia
  • Variant & Polymorphism SNP
  • increasing the risk of obesity
  • HTR2C:c.1-142948(GT)n associated with an increased risk of the metabolic syndrome in patients with schizophrenia (Mulder 2007)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse model lacking MBII-52 snoRNAs shows differences in pre-mRNA processing of the serotonin receptor (Kishore 2010)