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FLASH GENE
Symbol HTR2A contributors: mct/ - updated : 11-02-2013
HGNC name 5-hydroxytryptamine (serotonin) receptor 2A
HGNC id 5293
Location 13q14.2      Physical location : 47.407.512 - 47.471.169
Synonym name
  • 5-HT2 receptor
  • serotonin receptor 2A
  • serotonin 5-HT-2A receptor
  • Synonym symbol(s) HTR2, 5HT2, 5HT2A, 2AR
    DNA
    TYPE functioning gene
    STRUCTURE 63.48 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - D13S21 - ESD ,HTR2A - RB1 - D13S25 - qter
    Text see RB1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3564 - 471 - 1998 9729300
    3 - 2824 - 387 - 1998 9729300
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortex predominantly Homo sapiensAdult
     brainhindbraincerebellum moderately Homo sapiensAdult
    Reproductivemale systemtestis  lowly
    Visualeye   lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervouspyramidal cell Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    IMPRINTING paternally
    text paternally imprinted in some individuals (polymorphic imprinting)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a seven transmembrane segments (7TM_1) receptor
  • a PDZ domain-binding motif
  • HOMOLOGY
    interspecies homolog to rattus Htr2a (91.30 pc)
    homolog to murine Htr2a (91.51 pc)
    Homologene
    FAMILY
  • G-protein coupled receptor superfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • 5-hydroxytryptamine (serotonin) receptor, subtype 2A activating the phosphatidylinositol cycle
  • rapid modulation of spine morphology by HTR2A through kalirin-7 signaling
  • participates in diverse psychiatric disorders by regulating the activity of serotonin
  • participates in human spatial cognitive abilities and spatial working memory
  • undergoes constitutive and agonist-dependent internalization
  • involved in tracheal smooth muscle contraction, bronchoconstriction and control of aldosterone production
  • GRM2 and HTR2A form a functional heteromeric complex through which hallucinogenic drugs cross-signal to the Gi-coupled receptor
  • its activation upregulates the function of the neuronal K-Cl cotransporter SLC12A5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • HTR2A/GRM2 complex integrates serotonin and glutamate signaling to regulate the sensory gating functions of the cortex, a process that is disrupted in psychosis
  • HTR2A/GRM2 complex is necessary for the neuropsychological responses induced by hallucinogens 8)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • INADL
  • CASK
  • APBA1
  • DLG1
  • DLG4
  • target of several hallucinogens, antipsychotics, anxiolytics, and antidepressants
  • interacting with CBL (C-terminal region plays a crucial role in the temporal and spatial control of HTR2A recycling)
  • heteromeric complex between the HTR2A and GRM2, integrates ligand input, modulating signaling output and behavioral changes
  • HTR2A, HTR2B, HTR2C are implicated as being critical for induction of PTHLH and RUNX2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in brain from untreated schizophrenic subjects
    constitutional     --over  
    significantly higher level of HTR2A mRNA in platelets of patients with autistic spectrum disorders
    Susceptibility
  • to schizophrenia
  • to autism, bipolar 1 disorder
  • to panic disorder
  • to alcohol dependence
  • Variant & Polymorphism SNP , other
  • SNP in autism and in bipolar 1 disorder
  • allele T-102 increasing thre risk of schizophrenia
  • A allele may contribute to racial differences in outcomes of antidepressant treatment
  • a potential role of the T102C HTR2A polymorphism in development of alcohol dependence
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    complex HTR2A/GRM2 is a promising new target for the treatment of psychosis
    ANIMAL & CELL MODELS