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Symbol HTR2A contributors: mct/ - updated : 11-02-2013
HGNC name 5-hydroxytryptamine (serotonin) receptor 2A
HGNC id 5293
Location 13q14.2      Physical location : 47.407.512 - 47.471.169
Synonym name
  • 5-HT2 receptor
  • serotonin receptor 2A
  • serotonin 5-HT-2A receptor
  • Synonym symbol(s) HTR2, 5HT2, 5HT2A, 2AR
    TYPE functioning gene
    STRUCTURE 63.48 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - D13S21 - ESD ,HTR2A - RB1 - D13S25 - qter
    Text see RB1
    Physical map
    LOC387923 13 similar to ribosome associated membrane protein 4 TSC22 13q14 transforming growth factor beta-stimulated protein TSC-22 LOC341659 13q14.11 similar to SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1 NUFIP1 13q14 nuclear fragile X mental retardation protein interacting protein 1 LSR7 13q13-q14 lipopolysaccharide specific response-7 protein GTF2F2 13q14 general transcription factor IIF, polypeptide 2, 30kDa KCTD4 13q14.12-q14.13 potassium channel tetramerisation domain containing 4 TPT1 13q14.1-q14.2 tumor protein, translationally-controlled 1 LOC338851 13q14.11 similar to Reticulocalbin 1 precursor LOC253512 13q14.11 hypothetical protein LOC253512 LOC390401 13 similar to peptidyl-Pro cis trans isomerase COG3 13q14.11 component of oligomeric golgi complex 3 FLJ32682 13q14.11 hypothetical protein FLJ32682 LOC390402 13 similar to Aldose reductase (AR) (Aldehyde reductase) NURIT 13q14.11 testis-specific leucine zipper protein nurit LOC283514 13q14.11 similar to seven in absentia 2 KIAA0853 13q14.11 KIAA0853 CPB2 13q14.11 carboxypeptidase B2 (plasma, carboxypeptidase U) LCP1 13q14.3 lymphocyte cytosolic protein 1 (L-plastin) LOC220416 13q14.11 similar to Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8) LOC390403 13 similar to hypothetical protein FLJ20457 C13orf18 13q14.11 chromosome 13 open reading frame 18 LOC81993 13q14-q21 COX17 pseudogene CHDC1 13q14.11 calponin homology (CH) domain containing 1 ESD 13q14.1-q14.2 esterase D/formylglutathione hydrolase HTR2A 13q14.3 5-hydroxytryptamine (serotonin) receptor 2A SUCLA2 13q12.2-q13.3 succinate-CoA ligase, ADP-forming, beta subunit NUDT15 13q14.12 nudix (nucleoside diphosphate linked moiety X)-type motif 15 VDRIP 13q14.12 vitamin D receptor interacting protein ITM2B 13q14.3 integral membrane protein 2B RB1 13q14.2 retinoblastoma 1 (including osteosarcoma) P2RY5 13q14 purinergic receptor P2Y, G-protein coupled, 5 CHC1L 13q14.3 chromosome condensation 1-like CYSLTR2 13q14.12-p21.1 cysteinyl leukotriene receptor 2 LOC338099 13q13 proteasome activator subunit 2 pseudogene KIAA0970 13q14.11 proteasome activator subunit 2 pseudogene RAD17P2 13q14.3 RAD17 homolog (S. pombe) pseudogene 2 COX7CP1 13q14-q21 cytochrome c oxidase subunit VIIc pseudogene 1 LOC387924 13 similar to hypothetical protein FLJ10826 GPR38 13q14-q21 G protein-coupled receptor 38 CDADC1 13q14.12 cytidine and dCMP deaminase domain containing 1 FLJ12577 13q14.12 hypothetical protein FLJ12577
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3564 - 471 - 1998 9729300
    3 - 2824 - 387 - 1998 9729300
    Type restricted
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortex predominantly Homo sapiensAdult
     brainhindbraincerebellum moderately Homo sapiensAdult
    Reproductivemale systemtestis  lowly
    Visualeye   lowly
    SystemCellPubmedSpeciesStageRna symbol
    Nervouspyramidal cell Homo sapiensAdult
    cell lineage
    cell lines
    at STAGE
    physiological period fetal
    IMPRINTING paternally
    text paternally imprinted in some individuals (polymorphic imprinting)
  • a seven transmembrane segments (7TM_1) receptor
  • a PDZ domain-binding motif
    interspecies homolog to rattus Htr2a (91.30 pc)
    homolog to murine Htr2a (91.51 pc)
  • G-protein coupled receptor superfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • 5-hydroxytryptamine (serotonin) receptor, subtype 2A activating the phosphatidylinositol cycle
  • rapid modulation of spine morphology by HTR2A through kalirin-7 signaling
  • participates in diverse psychiatric disorders by regulating the activity of serotonin
  • participates in human spatial cognitive abilities and spatial working memory
  • undergoes constitutive and agonist-dependent internalization
  • involved in tracheal smooth muscle contraction, bronchoconstriction and control of aldosterone production
  • GRM2 and HTR2A form a functional heteromeric complex through which hallucinogenic drugs cross-signal to the Gi-coupled receptor
  • its activation upregulates the function of the neuronal K-Cl cotransporter SLC12A5
    signaling neurotransmission
    a component
  • HTR2A/GRM2 complex integrates serotonin and glutamate signaling to regulate the sensory gating functions of the cortex, a process that is disrupted in psychosis
  • HTR2A/GRM2 complex is necessary for the neuropsychological responses induced by hallucinogens 8)
    small molecule
  • CASK
  • APBA1
  • DLG1
  • DLG4
  • target of several hallucinogens, antipsychotics, anxiolytics, and antidepressants
  • interacting with CBL (C-terminal region plays a crucial role in the temporal and spatial control of HTR2A recycling)
  • heteromeric complex between the HTR2A and GRM2, integrates ligand input, modulating signaling output and behavioral changes
  • HTR2A, HTR2B, HTR2C are implicated as being critical for induction of PTHLH and RUNX2
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in brain from untreated schizophrenic subjects
    constitutional     --over  
    significantly higher level of HTR2A mRNA in platelets of patients with autistic spectrum disorders
  • to schizophrenia
  • to autism, bipolar 1 disorder
  • to panic disorder
  • to alcohol dependence
  • Variant & Polymorphism SNP , other
  • SNP in autism and in bipolar 1 disorder
  • allele T-102 increasing thre risk of schizophrenia
  • A allele may contribute to racial differences in outcomes of antidepressant treatment
  • a potential role of the T102C HTR2A polymorphism in development of alcohol dependence
  • Candidate gene
    Therapy target
    complex HTR2A/GRM2 is a promising new target for the treatment of psychosis