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FLASH GENE

Symbol

HTR1B

contributors: mct - updated : 16-01-2006

HGNC name	5-hydroxytryptamine (serotonin) receptor 1B
HGNC id	5287

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q13      Physical location : 78.171.947 - 78.173.120
Synonym symbol(s)	HTR1DB, HTR1D2, 5-HT1B, S12

DNA

TYPE	like-sequence
SPECIAL FEATURE	arranged in tandem
STRUCTURE	1.00 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Nervous brain           brain basal nuclei striatum       brain forebrain cerebral cortex

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	inhibiting adenylate cyclase
	playing a crucial role in regulating serotonin neurotransmission

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with P11 (modulation of its function)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in depression-like states

Susceptibility

to attention-deficit/hyperactivity disorder with preferential transmission of paternal alleles to suicide

Variant & Polymorphism other	A-161T locus, which seems to impact HTR1B transcription, could play a role in suicide predisposition by means of mediating impulsive-aggressive behaviors

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS