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FLASH GENE
Symbol HTN3 contributors: - updated : 28-03-2003
HGNC name histatin 3
HGNC id 5284
Location 4q13      Physical location : 70.894.129 - 70.902.255
Synonym name histatin 5
Synonym symbol(s) HIS2, HIS3, HTN2, HTN5
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC391663 4 similar to speckle-type POZ protein FLJ21934 4q13.3 hypothetical protein FLJ21934 LOC391664 4 similar to speckle-type POZ protein UGT2B27P 4q13 UDP glycosyltransferase 2 family, polypeptide B27 pseudogene UGT2B26P 4q13 UDP glycosyltransferase 2 family, polypeptide B26 pseudogene UGT2B7 4q13 UDP glycosyltransferase 2 family, polypeptide B7 LOC391665 4 similar to UDP-glucuronosyltransferase 2A1 precursor LOC391666 4 similar to RSDK2559 UGT2B11 4q13.3 UDP glycosyltransferase 2 family, polypeptide B11 LOC391667 4 similar to RSDK2559 UGT2B28 4q13.3 UDP glycosyltransferase 2 family, polypeptide B28 LOC391668 4 similar to RSDK2559 UGT2B25P 4q13 UDP glycosyltransferase 2 family, polypeptide B25 pseudogene UGT2B24P 4q13 UDP glycosyltransferase 2 family, polypeptide B24 pseudogene LOC389209 4 LOC389209 UGT2B4 4q13 UDP glycosyltransferase 2 family, polypeptide B4 UGT2A1 4q13 UDP glycosyltransferase 2 family, polypeptide A1 SULT1B1 4q13 sulfotransferase family, cytosolic, 1B, member 1 SULT1D1P 4q13.3 sulfotransferase family, cytosolic, 1B, member 1 STE 4q13.1 sulfotransferase, estrogen-preferring CSN1S1 4q21.1 casein alpha s1 CSN2 4q13.1-q21.1 casein beta STATH 4q11-q13 statherin HTN3 4q13 histatin 3 HTN1 4q13.3 histatin 1 FLJ20513 C4orf7 4q13 chromosome 4 open reading frame 7 CSN3 4q13.1-q21.1 casein kappa NYD-SP26 4q13.3 testis development protein NYD-SP26 PROL5 4q13.2 proline rich 5 (salivary) PROL3 4q13.3 proline rich 3 PROL1 4q13.2 proline rich 1 MUC7 4q13-q21 mucin 7, salivary ENAM 4q11-q21 enamelin IGJ 4q21 immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides SAS10 4q13.3 disrupter of silencing 10 RIPX 4q21.1 rap2 interacting protein x GRSF1 4q13 G-rich RNA sequence binding factor 1 MOB4A DCK 4q13.1-q21.1 deoxycytidine kinase
RNA
TRANSCRIPTS type messenger
text histatins 4-12 are derived from histatin 3 by proteolysis
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivetooth    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion saliva
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
histidine-rich protein
conjugated PhosphoP
HOMOLOGY
interspecies homolog to C.elegans F26A10.1
intraspecies homolog to HTN1
Homologene
FAMILY histatin family of small, histidine-rich, salivary proteins
CATEGORY immunity/defense , secretory
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • having important non-immunological, anti-microbial function in the oral cavity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS ossification
    PATHWAY
    metabolism other
    signaling
    xenobiotic metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS