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FLASH GENE
Symbol HTATIP2 contributors: mct - updated : 24-01-2024
HGNC name HIV-1 Tat interactive protein 2, 30kDa
HGNC id 16637
Location 11p15.1      Physical location : 20.385.230 - 20.405.329
Synonym name
  • oxidoreductase HTATIP2
  • Tat-interacting protein (30kD)
  • short chain dehydrogenase/reductase family 44U, member 1
  • Synonym symbol(s) CC3, TIP30, FLJ26963, SDR44U1
    EC.number 1.1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 20.10 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D11S1062 - D11S2840 - HTATIP2 - D11S4190 - D11S1233 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1719 27.1 242 - 2000 10698937
    apoptotic
    2 - 782 17 133 - 2000 10698937
  • unique short hydrophobic C terminus
  • antiapoptotic
  • 6 - 1509 - 276 - 2000 10698937
    6 - 1437 27.1 242 - 2000 10698937
    6 - 1404 27.1 242 - 2000 10698937
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • short chain dehydrogenases/reductases family
  • CATEGORY enzyme , transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • transcriptional coactivator, dual regulator of cell death
  • phosphorylates the heptapeptide repeats of the C-terminal domain (CTD) of the largest RNA polymerase II subunit in a Tat-dependent manner
  • involved in multiple functions including tumorigenic suppression, apoptosis induction and diminishing angiogenic properties
  • regulates TP53 mRNA stability and induces apoptosis by sensing of intracellular oxidative stress in hepatocellular carcinoma (HCC) cells
  • involved in cellular oxidative stress surveillance and induces apoptosis through stabilization of TP53 mRNA in HCC cells
  • plays an important role in predisposing hepatoblastoma cells to apoptosis through regulating expression levels of these genes
  • involved in multiple functions including metabolic suppression, apoptosis induction, and diminishing angiogenic properties
  • HTATIP2 complex regulates EGFR endocytosis by facilitating the transport of V-ATPases from trans-Golgi network to early endosomes.
  • functions as a tumor suppressor to inhibit EGFR cytoplasmic and nuclear signaling and suppress adenocarcinogenesis in the lung
  • is a negative regulator in oligodendrocyte development
  • plays a negative regulatory role in oligodendroglial differentiation
  • HTATIP2 is a new type 1 diabetes gene acting via T cell regulation
  • transcription factor known to suppress angiogenesis/arteriogenesis
  • regulates arteriogenic activity in monocytes from patients with limb ischemia
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell life, antiapoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component protein complex consisting HTATIP2, SH3GLB1, and ACSL4 that interacts with RAB5a and regulates EGFR endocytosis and signaling
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • enhancing HIV1 Tat-activated transcription
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in variant SLCC derived from tumors characterized by highly agressive metastatic behavior
    tumoral     --low  
    in gastric cancer cell lines
    tumoral     --low  
    in primary gliomas compared with normal brain tissue, and is associated with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • aberrant DNA methylation of HTATIP2 and UCHL1, may serve as a potential predictive biomarker for Cholangiocarcinoma (CCA)
  • may prove useful as a prognostic biomarker, for glioma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    independent prognostic factor and a potential therapeutic target for gastric cancer
    cancer  
    induces cell death and may act as an anticancer drug
    cardiovascularcardiomyopathy 
    could be a therapeutic target to counteract cardiac hypertrophy
    cancerbrainglioma/neuroblstoma
    is a potential target for glioma therapy
    ANIMAL & CELL MODELS
  • Tip30(-/-) mice displayed an increased myelin protein level at postnatal day 14 and 21
  • Tip30 deletion leads to spontaneous development of lung adenomas and adenocarcinomas in mice