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FLASH GENE
Symbol HTATIP2 contributors: mct - updated : 26-01-2009
HGNC name HIV-1 Tat interactive protein 2, 30kDa
HGNC id 16637
Location 11p15.1      Physical location : 20.385.230 - 20.405.329
Synonym name oxidoreductase HTATIP2
Synonym symbol(s) CC3, TIP30, FLJ26963, SDR44U1
EC.number 1.1.1.-
DNA
TYPE functioning gene
STRUCTURE 20.10 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D11S1062 - D11S2840 - HTATIP2 - D11S4190 - D11S1233 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1719 27.1 242 - 2000 10698937
apoptotic
2 - 782 17 133 - 2000 10698937
  • unique short hydrophobic C terminus
  • antiapoptotic
  • 6 - 1509 - 276 - 2000 10698937
    6 - 1437 27.1 242 - 2000 10698937
    6 - 1404 27.1 242 - 2000 10698937
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • short chain dehydrogenases/reductases family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,nucleus
    basic FUNCTION
  • transcriptional coactivator, dual regulator of cell death
  • phosphorylates the heptapeptide repeats of the C-terminal domain (CTD) of the largest RNA polymerase II subunit in a Tat-dependent manner
  • involved in multiple functions including tumorigenic suppression, apoptosis induction and diminishing angiogenic properties
  • regulates TP53 mRNA stability and induces apoptosis by sensing of intracellular oxidative stress in hepatocellular carcinoma (HCC) cells
  • involved in cellular oxidative stress surveillance and induces apoptosis through stabilization of TP53 mRNA in HCC cells
  • plays an important role in predisposing hepatoblastoma cells to apoptosis through regulating expression levels of these genes
  • involved in multiple functions including metabolic suppression, apoptosis induction, and diminishing angiogenic properties
  • HTATIP2 complex regulates EGFR endocytosis by facilitating the transport of V-ATPases from trans-Golgi network to early endosomes.
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell life, antiapoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component protein complex consisting HTATIP2, SH3GLB1, and ACSL4 that interacts with RAB5a and regulates EGFR endocytosis and signaling
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • enhancing HIV1 Tat-activated transcription
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in variant SLCC derived from tumors characterized by highly agressive metastatic behavior
    tumoral     --low  
    in gastric cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    independent prognostic factor and a potential therapeutic target for gastric cancer
    cancer  
    induces cell death and may act as an anticancer drug
    ANIMAL & CELL MODELS