basic FUNCTION
| transcriptional coactivator, dual regulator of cell death |
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phosphorylates the heptapeptide repeats of the C-terminal domain (CTD) of the largest RNA polymerase II subunit in a Tat-dependent manner |
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involved in multiple functions including tumorigenic suppression, apoptosis induction and diminishing angiogenic properties |
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regulates TP53 mRNA stability and induces apoptosis by sensing of intracellular oxidative stress in hepatocellular carcinoma (HCC) cells |
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involved in cellular oxidative stress surveillance and induces apoptosis through stabilization of TP53 mRNA in HCC cells |
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plays an important role in predisposing hepatoblastoma cells to apoptosis through regulating expression levels of these genes |
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involved in multiple functions including metabolic suppression, apoptosis induction, and diminishing angiogenic properties |
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HTATIP2 complex regulates EGFR endocytosis by facilitating the transport of V-ATPases from trans-Golgi network to early endosomes. |
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functions as a tumor suppressor to inhibit EGFR cytoplasmic and nuclear signaling and suppress adenocarcinogenesis in the lung |
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is a negative regulator in oligodendrocyte development |
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plays a negative regulatory role in oligodendroglial differentiation |
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HTATIP2 is a new type 1 diabetes gene acting via T cell regulation |
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transcription factor known to suppress angiogenesis/arteriogenesis |
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regulates arteriogenic activity in monocytes from patients with limb ischemia |