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FLASH GENE
Symbol HSPBP1 contributors: mct - updated : 08-01-2015
HGNC name HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HGNC id 24989
Location 19q13.42      Physical location : 55.773.591 - 55.791.751
Genatlas name hsp70-interacting protein
Synonym name
  • heat shock protein-binding protein 1
  • Hsp72-binding protein 1
    • Synonym symbol(s) HSPBP, HspBP2, PP1845, FES1
    DNA
    TYPE functioning gene
    STRUCTURE 18.16 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1925 - 359 - 2006 16677834
    9 - 1816 - 359 - 2006 16677834
    - - 1715 - 405 - 2006 16677834
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast Fes1
    Homologene
    FAMILY Hsp70 co-chaperone family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • nucleotide exchange factors that exhibit varying degrees of compartment and species specificity
  • extracellular HSPBP1 and HSPA1A synergistically activate epidermal growth factor receptor
  • may play a role in tumor (dys)regulation of chaperone proteins, and HSPBP1 may have extracellular roles with therapeutic implications
  • HSPBP1 and BAG-1M differentially regulate steroid hormone receptor function
  • affects chaperone expression at a posttranslational level by inhibiting the ubiquitylation and proteasomal degradation of inducible HSP70 proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between HSBP1 and the ATPase domain of the major heat shock protein HSPA4 up-regulates nucleotide exchange and reduces the affinity between HSPA4 and the peptide in its peptide-binding site
  • HSPBP1 incapacitates the HSPA4-PGLYRP1 complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • male Hspbp1(-/-) mice are sterile because of impaired meiosis and massive apoptosis of spermatocytes