Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

HSPB6

contributors: mct/pgu - updated : 08-09-2014

HGNC name	heat shock protein, alpha-crystallin-related, B6
HGNC id	26511

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.12      Physical location : 36.245.469 - 36.247.930
Synonym name	heat-shock protein beta-6
	heat-shock 20 kDa-like protein p20
Synonym symbol(s)	FLJ32389, Hsp20

DNA

TYPE	functioning gene
STRUCTURE	2.46 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_144617 3 - 1480 NP_653218 - 160 - 2004 14717697

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous nerve       highly   nerve cranial nerve     highly Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Muscular       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a unique N terminus
	a consensus motif (RRAS) for protein kinase A(PKA)/protein kinase G-dependent phosphorylation at Ser16
	a conserved alpha-crystallin domain at the C terminus, which facilitates the chaperone activity

mono polymer

monomer , dimer

HOMOLOGY

Homologene

FAMILY

small heat shock protein (HSP20) family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	secreted through exosomes, independent of the endoplasmic reticulum-Golgi pathway

basic FUNCTION	protects cardiomyocytes against apoptosis (Nicolaou 2008)
	increases in HSPB6 levels can protect against LPS-induced cardiac apoptosis and dysfunction, associated with inhibition of NF-kappaB activity
	bind to unfolded or misfolded proteins and protect them from aggregation
	in the heart, the small HSPB6 has emerged as a key mediator of protection against apoptosis, remodeling, and ischemia/reperfusion injury
	novel regulator of sarcoplasmic reticulum Ca cycling by targeting the PPP1CC-PLN axis
	its acetylation regulates human myometrial activity
	serves as a novel cardiokine in regulating myocardial angiogenesis through activation of the KDR signaling cascade

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

may exist as disulfide-linked dimer and monomer

INTERACTION

DNA

RNA

small molecule

protein	interacting with HSP22
	binds to BAG3 through the hydrophobic groove formed by its strands beta4 and beta8, a region previously known to be responsible for the formation and stability of higher-order oligomers of many sHsps (small Hsps)
	HDAC8 is a non-nuclear lysine deacetylase (KDAC) that can interact with HSPB6 to affect its acetylation
	YWHAZ monomeric form interacts with MAPT and with the HSPB6 protein
	interaction between HSPB6 and KDR
	interacton with cofilin (might affect potentially interaction of 14-3-3 with protein phosphatases and/or protein kinases involved in dephosphorylation or phosphorylation of cofilin and by this means regulate cofilin-dependent reorganization of cytoskeleton)
	AKAP13 may serve an ancillary cardioprotective role by favouring the association of PRKACA with HSPB6

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism other	mutation P20L is associated with structural alterations, diminished phosphorylation at Ser16, and loss of the cardioprotective effects under stress conditions

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular     dual benefit of targeting HSPB6 in heart disease cardiovascular atheroma cardiac phosphorylation of HSPB6 at serine 16 may represent a potential therapeutic target in ischemic heart disease immunology infectious   may be a new therapeutic agent for the treatment of sepsis

ANIMAL & CELL MODELS