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FLASH GENE
Symbol HSPB2 contributors: mct - updated : 12-11-2016
HGNC name heat shock 27kDa protein 2
HGNC id 5247
Location 11q23.1      Physical location : 111.783.459 - 111.784.817
Synonym name myotonic dystrophy protein kinase binding protein
Synonym symbol(s) MKBP, HSP27
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
text located near the 5' flanking region of the CRYAB gene in a head to head orientation manner
STRUCTURE 1.36 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 858 - 182 - 1997 9344664
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinethyroid   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  predominantly
Muscularstriatumcardiac  
Muscularstriatumskeletal moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyoblast
Muscularmyocyte
Reproductiveoocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminus involved in multimerization
  • a C terminus with the alpha crystallin domain responsible for chaperone function
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Hspb2 (97.3pc)
    ortholog to murine Hspb2 (96.7pc)
    Homologene
    FAMILY
  • alpha crystallin/small hsp family
  • small heat shock protein (HSP20) family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text myofibrils, neuromuscular junctions
    basic FUNCTION
  • potentially involved in chaperone activity
  • involved in maintenance of cytoskeletal network in muscle (potential role in pathogenesis of myotonic dystrophy)
  • acting as an enzyme activator
  • protects hippocampal progenitor cells from glucocorticoid-induced apoptotic cell death
  • role in regulating AKT1 activation and cellular apoptosis by mediating interaction between AKT1 and its upstream activator MAPKAPK2
  • may be involved in the pathogenesis of myotonic dystrophy and contribute to the neuropathology in both Alzheimer disease and hereditary cerebral hemorrhage with amyloidosis, Dutch type
  • ADP-induced phosphorylation of HSP27 via MAPK3 and/or MAPK14 is sufficient for platelet granule secretion but not for platelet aggregation
  • chaperone of the myotonic dystrophy protein kinase, having a function as a novel inhibitor of apical caspase activation in the extrinsic apoptotic pathway
  • inhibits the extrinsic apoptotic pathway by suppressing apical caspases-8 and 10 activation, thereby blocking downstream apoptotic events, such as BID cleavage and caspase-3 activation
  • anti-apoptotic protein that negatively regulates apical caspase activation in the extrinsic apoptotic pathway
  • may be playing a new role in the antiapoptotic action triggered by 17beta-estradiol by modulating CASP3 activity and stabilizing EESR2 in skeletal muscle cells
  • facilitates the palmitoylation and plasma membrane translocation of the three classes of sex steroid receptors
  • multifunctional protein that participates in ubiquitination of proteins for their degradation by proteasomes
  • modulates HNRNPD proteolysis and AU-rich element-mediated mRNA degradation
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with HSPB3 during myogenic differentiation, but biochemical properties of the HSPB2/B3 complex are distinctly different from those of other small heat-shock proteins, indicating that the HSPB2/B3 assembly is likely to possess cellular functions other than those of its family members
  • phosphorylated by the kinase mitogen-activated protein kinase-activated protein kinase 2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding and activating MDPK
  • HSPB8
  • interacts with estrogen receptors (ER) beta (ESR2) in mitochondria
  • binds to a motif in estrogen receptor alpha (ESR1) and promotes palmitoylation of the steroid receptors
  • facilitates the trafficking of endogenous ESR1 to the plasma membrane
  • TGFB1I1 and HSPB1, HSPB2 are effectors of NOX4 required for TGFB1-stimulated Focal adhesions (FAs) formation, adhesion strength and migration in vascular smooth muscle cell
  • EXOC3 is involved in the enhancement of cell migration and suppression of apoptosis through the activation of HSPB1, HSPB2 or MAPK14 phosphorylation
  • cell & other
    REGULATION
    induced by not induced by heat shock
    Other
  • phosphorylated by the kinase mitogen-activated protein kinase-activated protein kinase 2
  • ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    confers long-lasting neuroprotection against ischemic brain injury via a previously unexplored association and inhibition of MAP3K5 signaling
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • target for interrupting signaling from membrane sex steroid receptors to tumor biology in hormone-responsive cancers )
  • ANIMAL & CELL MODELS
  • downregulation of Hspb2 improved the maturation of mouse oocytes, while increased early stage of apoptosis in oocytes by inducing the activation of extrinsic, caspase 8-mediated pathway