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FLASH GENE
Symbol HSPB2 contributors: mct - updated : 12-11-2010
HGNC name heat shock 27kDa protein 2
HGNC id 5247
Location 11q23.1      Physical location : 111.783.459 - 111.784.817
Synonym name myotonic dystrophy protein kinase binding protein
Synonym symbol(s) MKBP, HSP27
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
text located near the 5' flanking region of the CRYAB gene in a head to head orientation manner
STRUCTURE 1.36 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
MGC50104 11q23.2 Similar to RIKEN cDNA 1810046K07 gene LOC120376 11q23.2 hypothetical protein LOC120376 POU2AF1 11q23.1 POU domain, class 2, associating factor 1 BTG4 11q23.2-q23.3 B-cell translocation gene 4 LOC387807 11 hypothetical gene supported by AK128145; BC039505 LOC143903 11q23.2 layilin SIK2 11q23.2 salt-inducible serine/threonine kinase 2 PPP2R1B 11q23 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform DIBD1 11q23 disrupted in bipolar affective disorder 1 C11orf1 11p15.5 chromosome 11 open reading frame 1 CRYAB 11q22.3-q23.1 crystallin, alpha B HSPB2 11q22.3-q23.1 heat shock 27kDa protein 2 MGC14839 11q23.2 similar to RIKEN cDNA 2310030G06 gene DIXDC1  DIX domain containing 1 LOC387808 11 similar to KIAA1735 protein DLAT 11q23.1 dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) LOC246731 11q23 peptidyl prolyl isomerase H (cyclophilin H) pseudogene LOC120379 11q23.2 hypothetical protein BC019238 FLJ10726 11q23.2 hypothetical protein FLJ10726 TIMM8B 11q23.1-q23.2 translocase of inner mitochondrial membrane 8 homolog B (yeast) SDHD 11q22.3-q23.1 succinate dehydrogenase complex, subunit D, integral membrane protein IL18 11q22.2-q22.3 interleukin 18 (interferon-gamma-inducing factor) TEX12 11q22 testis expressed sequence 12 BCDO2 11q22.3-q23.1 beta-carotene dioxygenase 2 MRPS36P4 11q23.2 mitochondrial ribosomal protein S36 pseudogene PTS 11q22.3-q23.3 6-pyruvoyltetrahydropterin synthase PLET1 11q23.2 placenta expressed transcript 1 LOC387809 11 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein LOC387810 11 LOC387810
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 858 - 182 - 1997 9344664
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinethyroid   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  predominantly
Muscularstriatumcardiac  
Muscularstriatumskeletal moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyoblast
Muscularmyocyte
Reproductiveoocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminus involved in multimerization
  • a C terminus with the alpha crystallin domain responsible for chaperone function
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Hspb2 (97.3pc)
    ortholog to murine Hspb2 (96.7pc)
    Homologene
    FAMILY
  • alpha crystallin/small hsp family
  • small heat shock protein (HSP20) family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text myofibrils, neuromuscular junctions
    basic FUNCTION
  • potentially involved in chaperone activity
  • involved in maintenance of cytoskeletal network in muscle (potential role in pathogenesis of myotonic dystrophy)
  • acting as an enzyme activator
  • protects hippocampal progenitor cells from glucocorticoid-induced apoptotic cell death
  • role in regulating AKT1 activation and cellular apoptosis by mediating interaction between AKT1 and its upstream activator MAPKAPK2
  • may be involved in the pathogenesis of myotonic dystrophy and contribute to the neuropathology in both Alzheimer disease and hereditary cerebral hemorrhage with amyloidosis, Dutch type
  • ADP-induced phosphorylation of HSP27 via MAPK3 and/or MAPK14 is sufficient for platelet granule secretion but not for platelet aggregation
  • chaperone of the myotonic dystrophy protein kinase, having a function as a novel inhibitor of apical caspase activation in the extrinsic apoptotic pathway
  • inhibits the extrinsic apoptotic pathway by suppressing apical caspases-8 and 10 activation, thereby blocking downstream apoptotic events, such as BID cleavage and caspase-3 activation
  • anti-apoptotic protein that negatively regulates apical caspase activation in the extrinsic apoptotic pathway
  • may be playing a new role in the antiapoptotic action triggered by 17beta-estradiol by modulating CASP3 activity and stabilizing EESR2 in skeletal muscle cells
  • facilitates the palmitoylation and plasma membrane translocation of the three classes of sex steroid receptors
  • multifunctional protein that participates in ubiquitination of proteins for their degradation by proteasomes
  • modulates HNRNPD proteolysis and AU-rich element-mediated mRNA degradation
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with HSPB3 during myogenic differentiation, but biochemical properties of the HSPB2/B3 complex are distinctly different from those of other small heat-shock proteins, indicating that the HSPB2/B3 assembly is likely to possess cellular functions other than those of its family members
  • phosphorylated by the kinase mitogen-activated protein kinase-activated protein kinase 2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding and activating MDPK
  • HSPB8
  • binds to a motif in estrogen receptor alpha (ESR1) and promotes palmitoylation of the steroid receptors
  • facilitates the trafficking of endogenous ESR1 to the plasma membrane
  • interacts with estrogen receptors (ER) beta (ESR2) in mitochondria
  • cell & other
    REGULATION
    induced by not induced by heat shock
    Other
  • phosphorylated by the kinase mitogen-activated protein kinase-activated protein kinase 2
  • ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    confers long-lasting neuroprotection against ischemic brain injury via a previously unexplored association and inhibition of MAP3K5 signaling
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • target for interrupting signaling from membrane sex steroid receptors to tumor biology in hormone-responsive cancers )
  • ANIMAL & CELL MODELS
  • downregulation of Hspb2 improved the maturation of mouse oocytes, while increased early stage of apoptosis in oocytes by inducing the activation of extrinsic, caspase 8-mediated pathway