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FLASH GENE
Symbol HSPA8 contributors: mct/ - updated : 12-09-2016
HGNC name heat shock 70kDa protein 8
HGNC id 5241
Location 11q24.1      Physical location : 122.928.200 - 122.932.844
Synonym name
  • heat shock cognate protein 54
  • heat shock cognate protein, 71-kDa
  • lipopolysaccharide-associated protein 1
  • N-myristoyltransferase inhibitor protein 71
  • LPS-associated protein 1
  • constitutive heat shock protein 70
  • epididymis luminal protein 33
  • epididymis secretory sperm binding protein Li 72p
  • Synonym symbol(s) HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP1, MGC131511, MGC29929, NIP71
    DNA
    TYPE functioning gene
    STRUCTURE 4.65 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC255849 11q24.1 hypothetical LOC255849 LOC390257 11 similar to Glutamine synthetase (Glutamate--ammonia ligase) LOC390258 11 similar to scaffold attachment factor B; heat-shock protein (HSP27) estrogen response element and TATA box-binding protein; HSP27 ERE-TATA-binding protein; glutathione S-transferase fusion protein; scaffold attachment factor B1 KIAA1959 11q24.1 nm23-phosphorylated unknown substrate CRTAM 11q22-q23 class-I MHC-restricted T cell associated molecule FLJ23554 11q24.1 hypothetical protein FLJ23554 LOC390259 11 similar to brain-specific homeodomain protein LOC341056 11q24.1 similar to SUMO-1 activating enzyme subunit 1; SUMO-1 activating enzyme E1 N subunit; sentrin/SUMO-activating protein AOS1; ubiquitin-like protein SUMO-1 activating enzyme HSPA8 11q23.3-q25 heat shock 70kDa protein 8 LOC85391 11q23.3-q25 RNA, small nucleolar ASAM 11q24.1 adipocyte-specific adhesion molecule LOC283157 11q24.1 similar to RIKEN cDNA A930008A22 KIAA1201 11q24.1 KIAA1201 protein SCN3B 11q23.3 sodium channel, voltage-gated, type III, beta ZNF202 11q23.3 zinc finger protein 202 LOC390260 11 similar to Olfactory receptor 6X1 LOC390261 11 similar to Olfactory receptor 6M1 LOC390262 11 similar to Olfactory receptor 6M1 LOC390263 11 similar to Olfactory receptor 6M1 LOC338661 11q24.1 hypothetical LOC338661 LOC338662 11q24.1 similar to Olfactory receptor 8D4 LOC219875 11q24.1 similar to Olfactory receptor 4D5 LOC219874 11q24.1 similar to Olfactory receptor 6T1 LOC219873 11q24.1 similar to Olfactory receptor 10S1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2276 - 646 - 2010 20018937
    8 - 1817 - 493 - 2010 20018937
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrineadrenal gland   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain   highly
    Respiratorylung    
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text cochlea
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two major domains: the N-terminal 44-kDa fragment which is a nucleotide binding domain
  • C-terminal 30-kDa domain which has the capacity to bind unfolded polypeptide substrates, divided into several subdomains, including a beta sandwich region containing a peptide substrate binding pocket and, an alpha-helical “lid” essential for tightly association of peptide
  • HOMOLOGY
    intraspecies homolog to aconitase,structurally
    Homologene
    FAMILY
  • heat shock protein 70 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • mediating the suppression of a stress-activated protein kinase JNK (SERK1)
  • increasing cell survival by inhibition of the apoptotic program
  • playing a role in in promoting tail-anchored protein biogenesis at the ER
  • plays a significant role in endothelial cells via the phosphatidylinositol 3-kinase/Akt pathway
  • role in cell proliferation that might account for the higher tumor growth of cancer cells overexpressing CTSD
  • prevents both MAPT aggregation and the inhibitory effects of preexisting MAPT aggregates on fast axonal transport
  • specific chaperone function for HSPA8 within viral factories, the sites of reovirus replication and assembly in cells
  • is a potential chaperone for the nuclear translocation of MAPK1
  • contribute to the long-term survival of spermatozoa inside the mammalian female reproductive tract
  • likely protects sperm survival through membrane repair mechanisms
  • acts as a molecular chaperone for the maintenance of intracellular proteins, which allows cancer cells to survive under proteotoxic stress
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding DNAJC13 through its DnaJ domain
  • binds to the microtubule-binding domain of tau, without an absolute requirement for tau phosphorylation
  • formation of a stable complex between chaperonin-containing TCP1 and HSPA8, two eukaryotic representatives of these chaperone families
  • direct binding between the N-terminus and the third cytoplasmic loop of SLC18A2, as well as, a region containing the substrate binding and the C-terminal domains of HSPA8
  • interaction between the head domain of KRT5 and HSPA8, a chaperone also involved in vesicle uncoating (this interaction is involved in melanosome formation or transport in keratinocytes)
  • interacts with both CDKN1C and CDKN1B and the subcellular localization of HSPA8 was critical to maintain HSC (hematopoietic stem cell) cycle kinetics
  • DNAJB6 binds HSPA8 and causes dephosphorylation of GSK3B at Ser 9 by recruiting protein phosphatase, PPP2CA
  • HSPA8 is a prerequisite for the surface translocation and angiogenic function of NCL, which suggests strategies to target both HSPA8 and NCL for more effective antiangiogenic therapies
  • is a potential interacting protein of MAPK1
  • plays a key role in CALM1-dependent nuclear import of SRY
  • dynamic C-terminal region of HSPA8 provides for flexibility between STUB1 and the chaperone
  • recruits PPP5C and activates its phosphatase activity which suggests dual roles for PPP5C that might link chaperone systems with signaling pathways in cancer and development
  • HSPA8 interacted with RAB1A in a chaperone-dependent manner
  • BBC3 associates with HSPA8/HSC70 (heat shock 70kDa protein 8), leading to its lysosome translocation and uptake
  • critical role of HSPA8 in SV40 ER-to-cytosol penetration and SGTA controls HSPA8 to impact this process
  • DNAJA2 and DNAJA1 were both important for CFTR folding, however overexpressing DNAJA2 but not DNAJA1 enhanced CFTR degradation at the endoplasmic reticulum by HSPA4/HSPA8 and the E3 ubiquitin ligase STUB1
  • cell & other
    REGULATION
    activated by BAG1-S isoform
    inhibited by BAG1-M isoform
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    constitutional     --low  
    of HSPA8 and HSPA9 was observed in Alzheimer disease across the three brain regions compared to the controls, suggesting their participation in AD pathogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • novel molecular basis for the protective effect of HSPA8 in tauopathies
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    may provide the basis for the development of new therapeutic strategies for angiogenesis
    neurologyepilepsy 
    could be a potential therapeutic target of Lafora disease
    ANIMAL & CELL MODELS