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FLASH GENE
Symbol HSPA4L contributors: mct - updated : 05-09-2006
HGNC name heat shock 70kDa protein 4-like
HGNC id 17041
Location 4q28.1      Physical location : 128.703.452 - 128.754.522
Synonym name
  • heat shock protein (hsp110 family)
  • heat shock protein apg-1
  • osmotic stress protein 94
  • Synonym symbol(s) APG1, OSP94, HSPG1R1
    DNA
    TYPE functioning gene
    STRUCTURE 51.07 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3284 94.4 839 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx    
    Hearing/Equilibriumear    
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratoryrespiratory tracttrachea   
    cell lineage
    cell lines
    fluid/secretion sperm
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Hspa4l (92.7pc)
    Homologene
    FAMILY
  • heat shock protein 70 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text may translocate to the nucleus after heat shock
    basic FUNCTION
  • having chaperone activity in vitro where it inhibits aggregation of citrate synthase
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
    cell & other
    REGULATION
    induced by by heat shock in germ cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS