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FLASH GENE
Symbol HSPA14 contributors: mct - updated : 26-09-2012
HGNC name heat shock 70kDa protein 14
HGNC id 29526
Location 10p13      Physical location : 14.880.260 - 14.913.738
Synonym name
  • heat shock protein HSP60
  • HSPA14 protein
  • Synonym symbol(s) HSP70-4, HSP70L1, MGC131990, HSP60
    DNA
    TYPE functioning gene
    STRUCTURE 33.48 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1810 - 509 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
    Endocrineparathyroid   highly
    Gustatory (taste)tongue    
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Hspa14 (91.0pc)
    homolog to rattus Hspa14 (90.2pc)
    Homologene
    FAMILY heat shock protein 70 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • involved in dendritic cells maturation and activation
  • induces phenotypic and functional maturation of dendritic cells in a TLR4-dependent manner
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    pathway (NBN-HSF4-HSPA4/HSPA14 axis) to induce migration, invasion, and transformation, suggesting the activation of multiple signaling events induced by NBN overexpression
    a component forms a stable complex with DNAJC2 (chaperones DNAJC2 and HSPA14 form the ribosome-associated complex)
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • interacting with NBN (NBN overexpression induced the expression of HSF4, which correlated with the expression of HSPA4 and HSPA14
  • binds directly to TLR4 on the surface of dendritic cells, activates MAPK and NFKB pathways
  • key receptor mediating the interaction of HSPA14 with dendritic cells and subsequently enhancing the induction of Th1 immune response by HSPA14/antigen fusion protein
  • key role for TLR4 in mediating HSPA14 interaction with dendritic cells
  • cell & other
    REGULATION
    induced by heat stress, TNF-alplha and phorbol esters
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS